Mediators of Ocular Angiogenesis

Overview

Journal J Genet

Specialty Genetics

Date 2010 Jan 22

PMID 20090210

Citations 74

Authors

Yureeda Qazi

Surekha Maddula

Balamurali K Ambati

Affiliations

Soon will be listed here.

Abstract

Angiogenesis is the formation of new blood vessels from pre-existing vasculature. Pathologic angiogenesis in the eye can lead to severe visual impairment. In our review, we discuss the roles of both pro-angiogenic and anti-angiogenic molecular players in corneal angiogenesis, proliferative diabetic retinopathy, exudative macular degeneration and retinopathy of prematurity, highlighting novel targets that have emerged over the past decade.

Citing Articles

Ref-1 is overexpressed in neovascular eye disease and targetable with a novel inhibitor.

Muniyandi A, Hartman G, Sishtla K, Rai R, Gomes C, Day K Angiogenesis. 2025; 28(1):11.

PMID: 39756006 DOI: 10.1007/s10456-024-09966-0.

Management of corneal neovascularization: Current and emerging therapeutic approaches.

Wu D, Chan K, Lim B, Lim D, Wong W, Chai C Indian J Ophthalmol. 2024; 72(Suppl 3):S354-S371.

PMID: 38648452 PMC: 467007. DOI: 10.4103/IJO.IJO_3043_23.

Serum and Vitreous Levels of Placenta Growth Factor in Diabetic Retinopathy Patients: Correlation With Disease Severity and Optical Coherence Tomographic Parameters.

Mesquita J, Santos F, Sousa J, Vaz-Pereira S, Tavares-Ratado P, Neves A Cureus. 2024; 16(2):e54862.

PMID: 38533176 PMC: 10964121. DOI: 10.7759/cureus.54862.

Assessment of the Effects of Sphingosine Kinase 1/Sphingosine-1-Phosphate on Microangiogenesis at Rat Myofascial Trigger Points Using Contrast-Enhanced Ultrasonography.

Fang X, Yin Y, Lun H, Liu Y, Zhu S J Pain Res. 2024; 17:609-621.

PMID: 38371480 PMC: 10871147. DOI: 10.2147/JPR.S437111.

Therapeutic eﬀects of a novel venom abstract (ZK002) solution in an alkali-burned corneal wound-healing model.

Peng W, Wang F, Yang S, Sun Q, Zhou H, Li X Mol Vis. 2024; 29:317-328.

PMID: 38264612 PMC: 10805332.

References

Mignatti P, Rifkin D . Nonenzymatic interactions between proteinases and the cell surface: novel roles in normal and malignant cell physiology. Adv Cancer Res. 1999; 78:103-57. DOI: 10.1016/s0065-230x(08)61024-6. View

Singh N, MacNamara E, Rashid S, Ambati J, Kontos C, Higgins E . Systemic soluble Tie2 expression inhibits and regresses corneal neovascularization. Biochem Biophys Res Commun. 2005; 332(1):194-9. DOI: 10.1016/j.bbrc.2005.04.108. View

Chen J, Smith L . Retinopathy of prematurity. Angiogenesis. 2007; 10(2):133-40. DOI: 10.1007/s10456-007-9066-0. View

OReilly M, Boehm T, Shing Y, Fukai N, Vasios G, Lane W . Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell. 1997; 88(2):277-85. DOI: 10.1016/s0092-8674(00)81848-6. View

Cao R, Wu H, Veitonmaki N, Linden P, Farnebo J, Shi G . Suppression of angiogenesis and tumor growth by the inhibitor K1-5 generated by plasmin-mediated proteolysis. Proc Natl Acad Sci U S A. 1999; 96(10):5728-33. PMC: 21928. DOI: 10.1073/pnas.96.10.5728. View

Penfold P, Provis J, Billson F . Age-related macular degeneration: ultrastructural studies of the relationship of leucocytes to angiogenesis. Graefes Arch Clin Exp Ophthalmol. 1987; 225(1):70-6. DOI: 10.1007/BF02155808. View

Malik R, Li C, Aziz W, Olson J, Vohra A, McHardy K . Elevated plasma CD105 and vitreous VEGF levels in diabetic retinopathy. J Cell Mol Med. 2005; 9(3):692-7. PMC: 6741635. DOI: 10.1111/j.1582-4934.2005.tb00499.x. View

Meleth A, Agron E, Chan C, Reed G, Arora K, Byrnes G . Serum inflammatory markers in diabetic retinopathy. Invest Ophthalmol Vis Sci. 2005; 46(11):4295-301. DOI: 10.1167/iovs.04-1057. View

Cross M, Claesson-Welsh L . FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition. Trends Pharmacol Sci. 2001; 22(4):201-7. DOI: 10.1016/s0165-6147(00)01676-x. View

10.

Soubrane G, Cohen S, Delayre T, Tassin J, Hartmann M, Coscas G . Basic fibroblast growth factor experimentally induced choroidal angiogenesis in the minipig. Curr Eye Res. 1994; 13(3):183-95. DOI: 10.3109/02713689408995776. View

11.

Schwesinger C, Yee C, Rohan R, Joussen A, Fernandez A, Meyer T . Intrachoroidal neovascularization in transgenic mice overexpressing vascular endothelial growth factor in the retinal pigment epithelium. Am J Pathol. 2001; 158(3):1161-72. PMC: 1850362. DOI: 10.1016/S0002-9440(10)64063-1. View

12.

Itoh N, Ornitz D . Evolution of the Fgf and Fgfr gene families. Trends Genet. 2004; 20(11):563-9. DOI: 10.1016/j.tig.2004.08.007. View

13.

Liu J, Lin T, Cole A, Wen R, Zhao L, Brescia M . Identification and characterization of small-molecule inhibitors of Tie2 kinase. FEBS Lett. 2008; 582(5):785-91. DOI: 10.1016/j.febslet.2008.02.003. View

14.

Teng Y, Cui H, Yang M, Song H, Zhang Q, Su Y . Protective effect of puerarin on diabetic retinopathy in rats. Mol Biol Rep. 2008; 36(5):1129-33. DOI: 10.1007/s11033-008-9288-2. View

15.

Ambati B, Joussen A, Ambati J, Moromizato Y, Guha C, Javaherian K . Angiostatin inhibits and regresses corneal neovascularization. Arch Ophthalmol. 2002; 120(8):1063-8. DOI: 10.1001/archopht.120.8.1063. View

16.

Yaylali V, Ohta T, Kaufman S, Maitchouk D, Beuerman R . In vivo confocal imaging of corneal neovascularization. Cornea. 1998; 17(6):646-53. DOI: 10.1097/00003226-199811000-00013. View

17.

Chan-Ling T, Gock B, Stone J . The effect of oxygen on vasoformative cell division. Evidence that 'physiological hypoxia' is the stimulus for normal retinal vasculogenesis. Invest Ophthalmol Vis Sci. 1995; 36(7):1201-14. View

18.

Itoh T, Tanioka M, Yoshida H, Yoshioka T, Nishimoto H, Itohara S . Reduced angiogenesis and tumor progression in gelatinase A-deficient mice. Cancer Res. 1998; 58(5):1048-51. View

19.

Friedlander M, Theesfeld C, Sugita M, Fruttiger M, Thomas M, Chang S . Involvement of integrins alpha v beta 3 and alpha v beta 5 in ocular neovascular diseases. Proc Natl Acad Sci U S A. 1996; 93(18):9764-9. PMC: 38503. DOI: 10.1073/pnas.93.18.9764. View

20.

Sakurai Y, Ohgimoto K, Kataoka Y, Yoshida N, Shibuya M . Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice. Proc Natl Acad Sci U S A. 2005; 102(4):1076-81. PMC: 545830. DOI: 10.1073/pnas.0404984102. View