Induced Pluripotent Stem Cells for Retinal Degenerative Diseases: a New Perspective on the Challenges

Overview

Journal J Genet

Specialty Genetics

Date 2010 Jan 22

PMID 20090205

Citations 29

Authors

Zi-Bing Jin

Satoshi Okamoto

Michiko Mandai

Masayo Takahashi

Affiliations

Soon will be listed here.

Abstract

Retinal degenerative diseases, including age-related macular degeneration and retinitis pigmentosa, are the prodominant causes of human blindness in the world; however, these diseases are difficult to treat. Currently, knowledge on the mechanisms of these diseases is still very limited and no radical drugs are available. Induced pluripotent stem (iPS) cells are an innovative technology that turns somatic cells into embryonic stem (ES)-like cells with pluripotent potential via the exogenous expression of several key genes. It can be used as an unlimited source for cell differentiation or tissue engineering, either of which is a promising therapy for human degenerative diseases. Induced pluripotent cells are both an unlimited source for retinal regeneration and an expectant tool for pharmaprojects and developmental or disease modelling. In this review, we try to summarize the advancement of iPS-based technologies and the potential utility for retinal degenerative diseases. We also discuss the challenges of using this technology in the retinology field.

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References

Woltjen K, Michael I, Mohseni P, Desai R, Mileikovsky M, Hamalainen R . piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature. 2009; 458(7239):766-70. PMC: 3758996. DOI: 10.1038/nature07863. View

Li Z, Wong F, Chang J, Possin D, Hao Y, Petters R . Rhodopsin transgenic pigs as a model for human retinitis pigmentosa. Invest Ophthalmol Vis Sci. 1998; 39(5):808-19. View

Raya A, Rodriguez-Piza I, Guenechea G, Vassena R, Navarro S, Barrero M . Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature. 2009; 460(7251):53-9. PMC: 2720823. DOI: 10.1038/nature08129. View

Takahashi K, Yamanaka S . Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006; 126(4):663-76. DOI: 10.1016/j.cell.2006.07.024. View

Dimos J, Rodolfa K, Niakan K, Weisenthal L, Mitsumoto H, Chung W . Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science. 2008; 321(5893):1218-21. DOI: 10.1126/science.1158799. View

Redenti S, Neeley W, Rompani S, Saigal S, Yang J, Klassen H . Engineering retinal progenitor cell and scrollable poly(glycerol-sebacate) composites for expansion and subretinal transplantation. Biomaterials. 2009; 30(20):3405-14. PMC: 4109162. DOI: 10.1016/j.biomaterials.2009.02.046. View

Rezai K, Semnani R, Patel S, Ernest J, van Seventer G . The immunogenic potential of human fetal retinal pigment epithelium and its relation to transplantation. Invest Ophthalmol Vis Sci. 1997; 38(12):2662-71. View

Huangfu D, Osafune K, Maehr R, Guo W, Eijkelenboom A, Chen S . Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol. 2008; 26(11):1269-75. DOI: 10.1038/nbt.1502. View

Lyssiotis C, Foreman R, Staerk J, Garcia M, Mathur D, Markoulaki S . Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proc Natl Acad Sci U S A. 2009; 106(22):8912-7. PMC: 2690053. DOI: 10.1073/pnas.0903860106. View

10.

Kim D, Kim C, Moon J, Chung Y, Chang M, Han B . Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell. 2009; 4(6):472-6. PMC: 2705327. DOI: 10.1016/j.stem.2009.05.005. View

11.

Osakada F, Jin Z, Hirami Y, Ikeda H, Danjyo T, Watanabe K . In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J Cell Sci. 2009; 122(Pt 17):3169-79. DOI: 10.1242/jcs.050393. View

12.

Ezashi T, Telugu B, Alexenko A, Sachdev S, Sinha S, Roberts R . Derivation of induced pluripotent stem cells from pig somatic cells. Proc Natl Acad Sci U S A. 2009; 106(27):10993-8. PMC: 2698893. DOI: 10.1073/pnas.0905284106. View

13.

Daley G, Lensch M, Jaenisch R, Meissner A, Plath K, Yamanaka S . Broader implications of defining standards for the pluripotency of iPSCs. Cell Stem Cell. 2009; 4(3):200-1. DOI: 10.1016/j.stem.2009.02.009. View

14.

Suzuki T, Akimoto M, Imai H, Ueda Y, Mandai M, Yoshimura N . Chondroitinase ABC treatment enhances synaptogenesis between transplant and host neurons in model of retinal degeneration. Cell Transplant. 2007; 16(5):493-503. DOI: 10.3727/000000007783464966. View

15.

Osakada F, Ikeda H, Mandai M, Wataya T, Watanabe K, Yoshimura N . Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells. Nat Biotechnol. 2008; 26(2):215-24. DOI: 10.1038/nbt1384. View

16.

Yu J, Vodyanik M, Smuga-Otto K, Antosiewicz-Bourget J, Frane J, Tian S . Induced pluripotent stem cell lines derived from human somatic cells. Science. 2007; 318(5858):1917-20. DOI: 10.1126/science.1151526. View

17.

Schwartz S, Aleman T, Cideciyan A, Swaroop A, Jacobson S, Stone E . De novo mutation in the RP1 gene (Arg677ter) associated with retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2003; 44(8):3593-7. DOI: 10.1167/iovs.03-0155. View

18.

Liu H, Zhu F, Yong J, Zhang P, Hou P, Li H . Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts. Cell Stem Cell. 2008; 3(6):587-90. DOI: 10.1016/j.stem.2008.10.014. View

19.

Lamba D, Gust J, Reh T . Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice. Cell Stem Cell. 2009; 4(1):73-9. PMC: 2713676. DOI: 10.1016/j.stem.2008.10.015. View

20.

Humayun M, de Juan Jr E, Cerro M, Dagnelie G, Radner W, Sadda S . Human neural retinal transplantation. Invest Ophthalmol Vis Sci. 2000; 41(10):3100-6. View