Now There Are Many (stages) Where Before There Was One: In Search of a Pathophysiological Classification of Cirrhosis

Overview

Journal Hepatology

Specialty Gastroenterology

Date 2010 Jan 16

PMID 20077563

Citations 171

Authors

Guadalupe Garcia-Tsao

Scott Friedman

John Iredale

Massimo Pinzani

Affiliations

Soon will be listed here.

Citing Articles

Disease trajectory and competing risks of patients with cirrhosis in the US.

Mohammadi M, Hasjim B, Balbale S, Polineni P, Huang A, Paukner M PLoS One. 2025; 20(2):e0313152.

PMID: 39951428 PMC: 11828360. DOI: 10.1371/journal.pone.0313152.

Immunosuppressive treatment in autoimmune decompensated cirrhosis, when to say enough: A retrospective analysis.

Barbero M, Burgos S, Roca I, Navarro L, Cairo F Medicine (Baltimore). 2025; 104(6):e41378.

PMID: 39928808 PMC: 11813046. DOI: 10.1097/MD.0000000000041378.

Advanced glycation end products and risk of mortality in patients with cirrhosis: a prospective cohort study.

Tabar M, Nilghaz M, Hekmatdoost A, Pashayee-Khamene F, Mokhtari Z, Karimi S Sci Rep. 2025; 15(1):4798.

PMID: 39922975 PMC: 11807124. DOI: 10.1038/s41598-025-89433-y.

Protective effect of long-chain polyunsaturated fatty acids on hepatorenal syndrome in rats.

Duailibe J, Viau C, Saffi J, Fernandes S, Porawski M World J Nephrol. 2024; 13(3):95627.

PMID: 39351184 PMC: 11439093. DOI: 10.5527/wjn.v13.i3.95627.

Liver fibrosis: Our evolving understanding.

Wells R Clin Liver Dis (Hoboken). 2024; 23(1):e0243.

PMID: 38961878 PMC: 11221862. DOI: 10.1097/CLD.0000000000000243.

References

Pinzani M, Rombouts K, Colagrande S . Fibrosis in chronic liver diseases: diagnosis and management. J Hepatol. 2005; 42 Suppl(1):S22-36. DOI: 10.1016/j.jhep.2004.12.008. View

Friedman S . Mechanisms of hepatic fibrogenesis. Gastroenterology. 2008; 134(6):1655-69. PMC: 2888539. DOI: 10.1053/j.gastro.2008.03.003. View

Poynard T, Bedossa P, Opolon P . Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups. Lancet. 1997; 349(9055):825-32. DOI: 10.1016/s0140-6736(96)07642-8. View

DAmico G, Garcia-Tsao G, Pagliaro L . Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies. J Hepatol. 2005; 44(1):217-31. DOI: 10.1016/j.jhep.2005.10.013. View

Krogsgaard K, Gluud C, Henriksen J, Christoffersen P . Correlation between liver morphology and portal pressure in alcoholic liver disease. Hepatology. 1984; 4(4):699-703. DOI: 10.1002/hep.1840040423. View

Iwakiri Y, Groszmann R . The hyperdynamic circulation of chronic liver diseases: from the patient to the molecule. Hepatology. 2006; 43(2 Suppl 1):S121-31. DOI: 10.1002/hep.20993. View

Blasco A, Forns X, Carrion J, Garcia-Pagan J, Gilabert R, Rimola A . Hepatic venous pressure gradient identifies patients at risk of severe hepatitis C recurrence after liver transplantation. Hepatology. 2006; 43(3):492-9. DOI: 10.1002/hep.21090. View

Casado M, Bosch J, Garcia-Pagan J, Bru C, Banares R, Bandi J . Clinical events after transjugular intrahepatic portosystemic shunt: correlation with hemodynamic findings. Gastroenterology. 1998; 114(6):1296-303. DOI: 10.1016/s0016-5085(98)70436-6. View

Groszmann R, Garcia-Tsao G, Bosch J, Grace N, Burroughs A, Planas R . Beta-blockers to prevent gastroesophageal varices in patients with cirrhosis. N Engl J Med. 2005; 353(21):2254-61. DOI: 10.1056/NEJMoa044456. View

10.

Fernandez M, Semela D, Bruix J, Colle I, Pinzani M, Bosch J . Angiogenesis in liver disease. J Hepatol. 2009; 50(3):604-20. DOI: 10.1016/j.jhep.2008.12.011. View

11.

Medina J, Arroyo A, Sanchez-Madrid F, Moreno-Otero R . Angiogenesis in chronic inflammatory liver disease. Hepatology. 2004; 39(5):1185-95. DOI: 10.1002/hep.20193. View

12.

Friedman S, Bansal M . Reversal of hepatic fibrosis -- fact or fantasy?. Hepatology. 2006; 43(2 Suppl 1):S82-8. DOI: 10.1002/hep.20974. View

13.

Vizzutti F, Arena U, Romanelli R, Rega L, Foschi M, Colagrande S . Liver stiffness measurement predicts severe portal hypertension in patients with HCV-related cirrhosis. Hepatology. 2007; 45(5):1290-7. DOI: 10.1002/hep.21665. View

14.

van Leeuwen D, Howe S, Scheuer P, Sherlock S . Portal hypertension in chronic hepatitis: relationship to morphological changes. Gut. 1990; 31(3):339-43. PMC: 1378280. DOI: 10.1136/gut.31.3.339. View

15.

Regev A, Berho M, Jeffers L, Milikowski C, Molina E, Pyrsopoulos N . Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection. Am J Gastroenterol. 2002; 97(10):2614-8. DOI: 10.1111/j.1572-0241.2002.06038.x. View

16.

Moitinho E, Escorsell A, Bandi J, Salmeron J, Garcia-Pagan J, Rodes J . Prognostic value of early measurements of portal pressure in acute variceal bleeding. Gastroenterology. 1999; 117(3):626-31. DOI: 10.1016/s0016-5085(99)70455-5. View

17.

Bosch J . Predictions from a hard liver. J Hepatol. 2006; 45(2):174-7. DOI: 10.1016/j.jhep.2006.06.002. View

18.

ISHAK K, Baptista A, Bianchi L, Callea F, De Groote J, Gudat F . Histological grading and staging of chronic hepatitis. J Hepatol. 1995; 22(6):696-9. DOI: 10.1016/0168-8278(95)80226-6. View

19.

Lim J, Groszmann R . Transient elastography for diagnosis of portal hypertension in liver cirrhosis: is there still a role for hepatic venous pressure gradient measurement?. Hepatology. 2007; 45(5):1087-90. DOI: 10.1002/hep.21731. View

20.

ANTHONY P, Ishak K, Nayak N, Poulsen H, Scheuer P, Sobin L . The morphology of cirrhosis. Recommendations on definition, nomenclature, and classification by a working group sponsored by the World Health Organization. J Clin Pathol. 1978; 31(5):395-414. PMC: 1145292. DOI: 10.1136/jcp.31.5.395. View