Human Immunoglobulin Allotypes: Possible Implications for Immunogenicity

Overview

Journal MAbs

Specialty Allergy & Immunology

Date 2010 Jan 16

PMID 20073133

Citations 97

Authors

Roy Jefferis

Marie-Paule Lefranc

Affiliations

Soon will be listed here.

Citing Articles

Immunosuppressive Therapy Modifies Anti-Spike IgG Subclasses Distribution After Four Doses of mRNA Vaccination in a Cohort of Kidney Transplant Recipients.

Juarez I, Perez-Flores I, Aiffil Meneses A, Lopez-Gomez A, Calvo Romero N, Rodriguez-Cubillo B Vaccines (Basel). 2025; 13(2).

PMID: 40006670 PMC: 11860609. DOI: 10.3390/vaccines13020123.

Regulators of placental antibody transfer through a modeling lens.

Wessel R, Dolatshahi S Nat Immunol. 2024; 25(11):2024-2036.

PMID: 39379658 DOI: 10.1038/s41590-024-01971-1.

Using IMGT unique numbering for IG allotypes and Fc-engineered variants of effector properties and half-life of therapeutic antibodies.

Lefranc M, Lefranc G Immunol Rev. 2024; 328(1):473-506.

PMID: 39367563 PMC: 11659927. DOI: 10.1111/imr.13399.

Living in LALA land? Forty years of attenuating Fc effector functions.

Hale G Immunol Rev. 2024; 328(1):422-437.

PMID: 39158044 PMC: 11659930. DOI: 10.1111/imr.13379.

Variation of the 3'RR1 HS1.2 Enhancer and Its Genomic Context.

Jodice C, Malaspina P, Ciminelli B, Martinez-Labarga C, Biancolella M, Novelli G Genes (Basel). 2024; 15(7).

PMID: 39062635 PMC: 11275349. DOI: 10.3390/genes15070856.

References

Gorman S, Clark M . Humanisation of monoclonal antibodies for therapy. Semin Immunol. 1990; 2(6):457-66. View

Niewold T, Murphy C, Weiss D, Solomon A . Characterization of a light chain product of the human JC lambda 7 gene complex. J Immunol. 1996; 157(10):4474-7. View

Reichert J, Valge-Archer V . Development trends for monoclonal antibody cancer therapeutics. Nat Rev Drug Discov. 2007; 6(5):349-56. DOI: 10.1038/nrd2241. View

Pandey J . Immunoglobulin GM and KM allotypes and vaccine immunity. Vaccine. 2000; 19(6):613-7. DOI: 10.1016/s0264-410x(00)00255-3. View

Kloosterman A . Application of immunoglobulin allotyping in forensic stain analysis: reliability and sensitivity of Gm and Km typing. Exp Clin Immunogenet. 1989; 6(1):123-32. View

Magdelaine-Beuzelin C, Vermeire S, Goodall M, Baert F, Noman M, Van Assche G . IgG1 heavy chain-coding gene polymorphism (G1m allotypes) and development of antibodies-to-infliximab. Pharmacogenet Genomics. 2009; 19(5):383-7. DOI: 10.1097/FPC.0b013e32832a06bf. View

Jefferis R, Reimer C, Skvaril F, de Lange G, Goodall D, Bentley T . Evaluation of monoclonal antibodies having specificity for human IgG subclasses: results of the 2nd IUIS/WHO collaborative study. Immunol Lett. 1992; 31(2):143-68. DOI: 10.1016/0165-2478(92)90141-a. View

Giudicelli V, Chaume D, Lefranc M . IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes. Nucleic Acids Res. 2004; 33(Database issue):D256-61. PMC: 539964. DOI: 10.1093/nar/gki010. View

Propert D . Immunoglobulin allotypes and RFLPs in disease association. Exp Clin Immunogenet. 1995; 12(3):198-205. DOI: 10.1159/000424872. View

10.

Lefranc G, Chaabani H, van Loghem E, Lefranc M, De Lange G, Helal A . Simultaneous absence of the human IgG1, IgG2, IgG4 and IgA1 subclasses: immunological and immunogenetical considerations. Eur J Immunol. 1983; 13(3):240-4. DOI: 10.1002/eji.1830130312. View

11.

GRUBB R . Agglutination of erythrocytes coated with incomplete anti-Rh by certain rheumatoid arthritic sera and some other sera; the existence of human serum groups. Acta Pathol Microbiol Scand. 1956; 39(3):195-7. View

12.

Pandey J, Nietert P, Klaamas K, Kurtenkov O . A genetic variant of immunoglobulin gamma2 is strongly associated with immunity to mucin 1 in patients with breast cancer. Cancer Immunol Immunother. 2009; 58(12):2025-9. PMC: 11030933. DOI: 10.1007/s00262-009-0709-4. View

13.

Granoff D, Suarez B, Pandey J, Shackelford P . Genes associated with the G2m(23) immunoglobulin allotype regulate the IgG subclass responses to Haemophilus influenzae type b polysaccharide vaccine. J Infect Dis. 1988; 157(6):1142-9. DOI: 10.1093/infdis/157.6.1142. View

14.

Hieter P, Hollis G, Korsmeyer S, Waldmann T, Leder P . Clustered arrangement of immunoglobulin lambda constant region genes in man. Nature. 1981; 294(5841):536-40. DOI: 10.1038/294536a0. View

15.

Rodriguez M, van der Pol W, Sanders L, van de Winkel J . Crucial role of FcgammaRIIa (CD32) in assessment of functional anti-Streptococcus pneumoniae antibody activity in human sera. J Infect Dis. 1999; 179(2):423-33. DOI: 10.1086/314603. View

16.

Walker M, Solomon A, Weiss D, DEUTSCH H, Jefferis R . Immunogenic and antigenic epitopes of Ig. XXV. Monoclonal antibodies that differentiate the Mcg+/Mcg- and Oz+/Oz- C region isotypes of human lambda L chains. J Immunol. 1988; 140(5):1600-4. View

17.

Hougs L, Svejgaard A, Barington T . The first constant-domain (CH1) exon of human IGHG2 is polymorphic and in strong linkage disequilibrium with the CH2 exon polymorphism encoding the G2m(n+) allotype in Caucasians. Immunogenetics. 2001; 52(3-4):242-8. DOI: 10.1007/s002510000278. View

18.

Dam T, Torres M, Brewer C, Casadevall A . Isothermal titration calorimetry reveals differential binding thermodynamics of variable region-identical antibodies differing in constant region for a univalent ligand. J Biol Chem. 2008; 283(46):31366-70. PMC: 2581562. DOI: 10.1074/jbc.M806473200. View

19.

Jenkins N . Modifications of therapeutic proteins: challenges and prospects. Cytotechnology. 2008; 53(1-3):121-5. PMC: 2267613. DOI: 10.1007/s10616-007-9075-2. View

20.

Scinicariello F, Engleman C, Jayashankar L, McClure H, Attanasio R . Rhesus macaque antibody molecules: sequences and heterogeneity of alpha and gamma constant regions. Immunology. 2003; 111(1):66-74. PMC: 1782391. DOI: 10.1111/j.1365-2567.2004.01767.x. View