Protein Modifications As Potential Biomarkers in Breast Cancer

Overview

Journal Biomark Insights

Publisher Sage Publications

Date 2010 Jan 15

PMID 20072669

Citations 25

Authors

Hongjun Jin

Richard C Zangar

Affiliations

Soon will be listed here.

Abstract

A variety of post-translational protein modifications (PTMs) are known to be altered as a result of cancer development. Thus, these PTMs are potentially useful biomarkers for breast cancer. Mass spectrometry, antibody microarrays and immunohistochemistry techniques have shown promise for identifying changes in PTMs. In this review, we summarize the current literature on PTMs identified in the plasma and tumor tissue of breast-cancer patients or in breast cell lines. We also discuss some of the analytical techniques currently being used to evaluate PTMs.

Citing Articles

Deciphering a proteomic signature for the early detection of breast cancer from breast milk: the role of quantitative proteomics.

Whitham D, Bruno P, Haaker N, Arcaro K, Pentecost B, Darie C Expert Rev Proteomics. 2024; 21(1-3):81-98.

PMID: 38376826 PMC: 11694492. DOI: 10.1080/14789450.2024.2320158.

XGDAG: explainable gene-disease associations via graph neural networks.

Mastropietro A, De Carlo G, Anagnostopoulos A Bioinformatics. 2023; 39(8).

PMID: 37531293 PMC: 10421968. DOI: 10.1093/bioinformatics/btad482.

Spatial Proteomics for the Molecular Characterization of Breast Cancer.

Brozova K, Hantusch B, Kenner L, Kratochwill K Proteomes. 2023; 11(2).

PMID: 37218922 PMC: 10204503. DOI: 10.3390/proteomes11020017.

Studying protein structure and function by native separation-mass spectrometry.

van Schaick G, Haselberg R, Somsen G, Wuhrer M, Dominguez-Vega E Nat Rev Chem. 2023; 6(3):215-231.

PMID: 37117432 DOI: 10.1038/s41570-021-00353-7.

Lysine Malonylation and Its Links to Metabolism and Diseases.

Zou L, Yang Y, Wang Z, Fu X, He X, Song J Aging Dis. 2023; 14(1):84-98.

PMID: 36818560 PMC: 9937698. DOI: 10.14336/AD.2022.0711.

References

Abd Hamid U, Royle L, Saldova R, Radcliffe C, Harvey D, Storr S . A strategy to reveal potential glycan markers from serum glycoproteins associated with breast cancer progression. Glycobiology. 2008; 18(12):1105-18. DOI: 10.1093/glycob/cwn095. View

Ouyang X, Gulliford T, Zhang H, Smith G, Huang G, Epstein R . Association of ErbB2 Ser1113 phosphorylation with epidermal growth factor receptor co-expression and poor prognosis in human breast cancer. Mol Cell Biochem. 2001; 218(1-2):47-54. DOI: 10.1023/a:1007249004222. View

Cao Y, Karsten U, Hilgers J . Immunohistochemical characterization of a panel of 56 antibodies with normal human small intestine, colon, and breast tissues. Tumour Biol. 1998; 19 Suppl 1:88-99. DOI: 10.1159/000056509. View

Lin E, Pollard J . Macrophages: modulators of breast cancer progression. Novartis Found Symp. 2004; 256:158-68. View

Barciszewska A, Murawa D, Gawronska I, Murawa P, Nowak S, Barciszewska M . Analysis of 5-methylcytosine in DNA of breast and colon cancer tissues. IUBMB Life. 2007; 59(12):765-70. DOI: 10.1080/15216540701697412. View

Storr S, Royle L, Chapman C, Abd Hamid U, Robertson J, Murray A . The O-linked glycosylation of secretory/shed MUC1 from an advanced breast cancer patient's serum. Glycobiology. 2008; 18(6):456-62. DOI: 10.1093/glycob/cwn022. View

Karihtala P, Winqvist R, Syvaoja J, Kinnula V, Soini Y . Increasing oxidative damage and loss of mismatch repair enzymes during breast carcinogenesis. Eur J Cancer. 2006; 42(15):2653-9. DOI: 10.1016/j.ejca.2006.05.037. View

Janke C, Rogowski K, van Dijk J . Polyglutamylation: a fine-regulator of protein function? 'Protein Modifications: beyond the usual suspects' review series. EMBO Rep. 2008; 9(7):636-41. PMC: 2475320. DOI: 10.1038/embor.2008.114. View

Brandon M, Baldi P, Wallace D . Mitochondrial mutations in cancer. Oncogene. 2006; 25(34):4647-62. DOI: 10.1038/sj.onc.1209607. View

10.

Czlapinski J, Bertozzi C . Synthetic glycobiology: Exploits in the Golgi compartment. Curr Opin Chem Biol. 2006; 10(6):645-51. DOI: 10.1016/j.cbpa.2006.10.009. View

11.

Madjd Z, Parsons T, Watson N, Spendlove I, Ellis I, Durrant L . High expression of Lewis y/b antigens is associated with decreased survival in lymph node negative breast carcinomas. Breast Cancer Res. 2005; 7(5):R780-7. PMC: 1242157. DOI: 10.1186/bcr1305. View

12.

Joshi G, Hardas S, Sultana R, St Clair D, Vore M, Butterfield D . Glutathione elevation by gamma-glutamyl cysteine ethyl ester as a potential therapeutic strategy for preventing oxidative stress in brain mediated by in vivo administration of adriamycin: Implication for chemobrain. J Neurosci Res. 2006; 85(3):497-503. DOI: 10.1002/jnr.21158. View

13.

Agnoletto M, Guecheva T, Donde F, de Oliveira A, Franke F, Cassini C . Association of low repair efficiency with high hormone receptors expression and SOD activity in breast cancer patients. Clin Biochem. 2007; 40(16-17):1252-8. DOI: 10.1016/j.clinbiochem.2007.08.017. View

14.

Wu R, Smith C, OMalley B . Transcriptional regulation by steroid receptor coactivator phosphorylation. Endocr Rev. 2005; 26(3):393-9. DOI: 10.1210/er.2004-0018. View

15.

Tomonaga T, Matsushita K, Yamaguchi S, Oh-Ishi M, Kodera Y, Maeda T . Identification of altered protein expression and post-translational modifications in primary colorectal cancer by using agarose two-dimensional gel electrophoresis. Clin Cancer Res. 2004; 10(6):2007-14. DOI: 10.1158/1078-0432.ccr-03-0321. View

16.

Pfister S, Rea S, Taipale M, Mendrzyk F, Straub B, Ittrich C . The histone acetyltransferase hMOF is frequently downregulated in primary breast carcinoma and medulloblastoma and constitutes a biomarker for clinical outcome in medulloblastoma. Int J Cancer. 2007; 122(6):1207-13. DOI: 10.1002/ijc.23283. View

17.

Sozzani P, Arisio R, Porpiglia M, Benedetto C . Is Sialyl Lewis x antigen expression a prognostic factor in patients with breast cancer?. Int J Surg Pathol. 2008; 16(4):365-74. DOI: 10.1177/1066896908324668. View

18.

Bransfield L, Rennie A, Visvanathan K, Odwin S, Kensler T, Yager J . Formation of two novel estrogen guanine adducts and HPLC/MS detection of 4-hydroxyestradiol-N7-guanine in human urine. Chem Res Toxicol. 2008; 21(8):1622-30. PMC: 2561950. DOI: 10.1021/tx800145w. View

19.

Heimburg J, Yan J, Morey S, Glinskii O, Huxley V, Wild L . Inhibition of spontaneous breast cancer metastasis by anti-Thomsen-Friedenreich antigen monoclonal antibody JAA-F11. Neoplasia. 2006; 8(11):939-48. PMC: 1716011. DOI: 10.1593/neo.06493. View

20.

Dube D, Bertozzi C . Glycans in cancer and inflammation--potential for therapeutics and diagnostics. Nat Rev Drug Discov. 2005; 4(6):477-88. DOI: 10.1038/nrd1751. View