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A Short-duration Dark Adaptation Protocol for Assessment of Age-related Maculopathy

Overview
Journal J Ocul Biol Dis Infor
Publisher Springer
Specialty Ophthalmology
Date 2010 Jan 15
PMID 20072631
Citations 58
Authors
Gregory R Jackson
John G Edwards
Affiliations
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Abstract

Dark adaptometry may be a useful diagnostic test and clinical trial endpoint for age-related maculopathy (ARM) because impaired night vision is a hallmark of early ARM. A novel dark adaptometer, the AdaptDx, was evaluated for the detection of ARM. The AdaptDx incorporates a 20-minute protocol optimized for the detection of ARM. ARM patients (N = 17) exhibited substantial dark adaptation impairment compared with normal adults (N = 17). The diagnostic sensitivity was 88% and the specificity was 100%. The diagnostic test characteristics of the AdaptDx are similar to previously reported studies using 60- to 120-minute protocols.

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