The Role of Ultraviolet Radiation in Melanomagenesis

Overview

Journal Exp Dermatol

Specialty Dermatology

Date 2010 Jan 14

PMID 20067521

Citations 34

Authors

Anna-Katharina von Thaler

York Kamenisch

Mark Berneburg

Affiliations

Soon will be listed here.

Abstract

The role of ultraviolet radiation (UV) in the pathogenesis has been discussed controversially for many decades. Studies in mice (SCID, HGF/SF, SV40T) which develop malignant melanoma, show a role of UVB in melanomagenesis. In contrast to this, the role of UVA is less clear. We will review the recent in vitro and in vivo data in support of the hypothesis that UVA is also involved in the development of malignant melanoma. The role of UVA in p53 activation, apoptosis, cell cycle arrest and photoproduct formation is discussed.

Citing Articles

Psoriasis and Seasonality: Exploring the Genetic and Epigenetic Interactions.

Niedzwiedz M, Skibinska M, Ciazynska M, Noweta M, Czerwinska A, Krzyscin J Int J Mol Sci. 2024; 25(21).

PMID: 39519223 PMC: 11547062. DOI: 10.3390/ijms252111670.

Putrescine Upregulates Melanogenesis Through Modulation of MITF Transcription Factor in B16F1 Mouse Melanoma Cells.

Talapphet N, Kim M Food Technol Biotechnol. 2024; 62(1):15-25.

PMID: 38601964 PMC: 11002443. DOI: 10.17113/ftb.62.01.24.8120.

Nanotechnology as a Promising Method in the Treatment of Skin Cancer.

Adamus-Grabicka A, Hikisz P, Sikora J Int J Mol Sci. 2024; 25(4).

PMID: 38396841 PMC: 10889690. DOI: 10.3390/ijms25042165.

Rutin Protects Fibroblasts from UVA Radiation through Stimulation of Nrf2 Pathway.

Tabolacci E, Tringali G, Nobile V, Duca S, Pizzoferrato M, Bottoni P Antioxidants (Basel). 2023; 12(4).

PMID: 37107196 PMC: 10135198. DOI: 10.3390/antiox12040820.

Role of ROS‑mediated autophagy in melanoma (Review).

Zhang X, Li H, Liu C, Yuan X Mol Med Rep. 2022; 26(4).

PMID: 35946460 PMC: 9434998. DOI: 10.3892/mmr.2022.12819.