Morphogen Gradient Formation

Overview

Journal Cold Spring Harb Perspect Biol

Specialties Biology
Molecular Biology

Date 2010 Jan 13

PMID 20066104

Citations 123

Authors

Ortrud Wartlick

Anna Kicheva

Marcos Gonzalez-Gaitan

Affiliations

Soon will be listed here.

Abstract

How morphogen gradients are formed in target tissues is a key question for understanding the mechanisms of morphological patterning. Here, we review different mechanisms of morphogen gradient formation from theoretical and experimental points of view. First, a simple, comprehensive overview of the underlying biophysical principles of several mechanisms of gradient formation is provided. We then discuss the advantages and limitations of different experimental approaches to gradient formation analysis.

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