Junctional Music That the Nucleus Hears: Cell-cell Contact Signaling and the Modulation of Gene Activity

Overview

Journal Cold Spring Harb Perspect Biol

Specialties Biology
Molecular Biology

Date 2010 Jan 13

PMID 20066098

Citations 44

Authors

Pierre D McCrea

Dongmin Gu

Maria S Balda

Affiliations

Soon will be listed here.

Abstract

Cell-cell junctions continue to capture the interest of cell and developmental biologists, with an emerging area being the molecular means by which junctional signals relate to gene activity in the nucleus. Although complexities often arise in determining the direct versus indirect nature of such signal transduction, it is clear that such pathways are essential for the function of tissues and that alterations may contribute to many pathological outcomes. This review assesses a variety of cell-cell junction-to-nuclear signaling pathways, and outlines interesting areas for further study.

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