Crosstalk Between Perivascular Adipose Tissue and Blood Vessels

Overview

Journal Curr Opin Pharmacol

Specialty Pharmacology

Date 2010 Jan 12

PMID 20060362

Citations 82

Authors

Srinivas Rajsheker

David Manka

Andra L Blomkalns

Tapan K Chatterjee

Lynn L Stoll

Neal L Weintraub

Affiliations

Soon will be listed here.

Abstract

Crosstalk between cells in the blood vessel wall is vital to normal vascular function and is perturbed in diseases such as atherosclerosis and hypertension. Perivascular adipocytes reside at the adventitial border of blood vessels but until recently were virtually ignored in studies of vascular function. However, perivascular adipocytes have been demonstrated to be powerful endocrine cells capable of responding to metabolic cues and transducing signals to adjacent blood vessels. Accordingly, crosstalk between perivascular adipose tissue (PVAT) and blood vessels is now being intensely examined. Emerging evidence suggests that PVAT regulates vascular function through numerous mechanisms, but evidence to date suggests modulation of three key aspects that are the focus of this review: inflammation, vasoreactivity, and smooth muscle cell proliferation.

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