Myofilament Length Dependent Activation

Overview

Journal J Mol Cell Cardiol

Specialty Cardiology & Vascular Diseases

Date 2010 Jan 8

PMID 20053351

Citations 154

Authors

Pieter P de Tombe

Ryan D Mateja

Kittipong Tachampa

Younss Ait Mou

Gerrie P Farman

Thomas C Irving

Affiliations

Soon will be listed here.

Abstract

The Frank-Starling law of the heart describes the interrelationship between end-diastolic volume and cardiac ejection volume, a regulatory system that operates on a beat-to-beat basis. The main cellular mechanism that underlies this phenomenon is an increase in the responsiveness of cardiac myofilaments to activating Ca(2+) ions at a longer sarcomere length, commonly referred to as myofilament length-dependent activation. This review focuses on what molecular mechanisms may underlie myofilament length dependency. Specifically, the roles of inter-filament spacing, thick and thin filament based regulation, as well as sarcomeric regulatory proteins are discussed. Although the "Frank-Starling law of the heart" constitutes a fundamental cardiac property that has been appreciated for well over a century, it is still not known in muscle how the contractile apparatus transduces the information concerning sarcomere length to modulate ventricular pressure development.

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