Human Tryptophan Oxygenase Localized to 4q31: Possible Implications for Alcoholism and Other Behavioral Disorders

Overview

Journal Genomics

Specialty Genetics

Date 1991 Feb 1

PMID 2004780

Citations 2

Authors

D E Comings

D Muhleman

G W Dietz Jr

T Donlon

Affiliations

Soon will be listed here.

Abstract

A human tryptophan oxygenase clone was isolated by screening a liver cDNA library with a rat tryptophan oxygenase cDNA clone. Analysis showed extensive homology between the rat and the human DNA and protein sequences. The combined use of cell hybrids and in situ hydridization indicated that human tryptophan oxygenase was localized to chromosome band 4q31. The tryptophan oxygenase gene may be important in some human behavior disorders, especially those associated with abnormalities of serotonin metabolism.

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