Discovery of Anticancer Agents of Diverse Natural Origin

Overview

Journal Pure Appl Chem

Specialty Chemistry

Date 2010 Jan 5

PMID 20046887

Citations 57

Authors

A Douglas Kinghorn

Esperanza J Carcache de Blanco

Hee-Byung Chai

Jimmy Orjala

Norman R Farnsworth

D Doel Soejarto

Nicholas H Oberlies

Mansukh C Wani

David J Kroll

Cedric J Pearce

Steven M Swanson

Robert A Kramer

William C Rose

Craig R Fairchild

Gregory D Vite

Stuart Emanuel

David Jarjoura

Frederick O Cope

Affiliations

Soon will be listed here.

Abstract

A collaborative multidisciplinary research project is described in which new natural product anticancer drug leads are obtained from a diverse group of organisms, constituted by tropical plants, aquatic cyanobacteria, and filamentous fungi. Information is provided on how these organisms are collected and processed. The types of bioassays are indicated in which crude extracts of these acquisitions are tested. Progress made in the isolation of lead bioactive secondary metabolites from three tropical plants is discussed.

Citing Articles

Strategies for the discovery of potential anticancer agents from plants collected from Southeast Asian tropical rainforests as a case study.

de Blanco E, Addo E, Rakotondraibe H, Soejarto D, Kinghorn A Nat Prod Rep. 2023; 40(7):1181-1197.

PMID: 37194649 PMC: 10524867. DOI: 10.1039/d2np00080f.

Discovery of Anticancer Agents of Diverse Natural Origin.

Aldrich L, Burdette J, de Blanco E, Coss C, Eustaquio A, Fuchs J J Nat Prod. 2022; 85(3):702-719.

PMID: 35213158 PMC: 9034850. DOI: 10.1021/acs.jnatprod.2c00036.

Natural Compounds as Target Biomolecules in Cellular Adhesion and Migration: From Biomolecular Stimulation to Label-Free Discovery and Bioactivity-Based Isolation.

Peter B, Boldizsar I, Kovacs G, Erdei A, Bajtay Z, Voros A Biomedicines. 2021; 9(12).

PMID: 34944597 PMC: 8698624. DOI: 10.3390/biomedicines9121781.

Targeting Drug Chemo-Resistance in Cancer Using Natural Products.

Talib W, Alsayed A, Barakat M, Abu-Taha M, Mahmod A Biomedicines. 2021; 9(10).

PMID: 34680470 PMC: 8533186. DOI: 10.3390/biomedicines9101353.

Antitumor potential of the protein phosphatase inhibitor, cantharidin, and selected derivatives.

Ren Y, Kinghorn A Bioorg Med Chem. 2021; 32:116012.

PMID: 33454654 PMC: 7854516. DOI: 10.1016/j.bmc.2021.116012.

References

Wall M, Wani M, Brown D, Fullas F, Olwald J, Josephson F . Effect of tannins on screening of plant extracts for enzyme inhibitory activity and techniques for their removal. Phytomedicine. 2012; 3(3):281-5. DOI: 10.1016/S0944-7113(96)80067-5. View

Burslem D, Garwood N, Thomas S . Ecology. Tropical forest diversity--the plot thickens. Science. 2001; 291(5504):606-7. DOI: 10.1126/science.1055873. View

Lee H, Lee J, Hwang B, Kim H, Lee J . Anti-angiogenic activities of gliotoxin and its methylthioderivative, fungal metabolites. Arch Pharm Res. 2001; 24(5):397-401. DOI: 10.1007/BF02975182. View

Pitman N, Jorgensen P . Estimating the size of the world's threatened flora. Science. 2002; 298(5595):989. DOI: 10.1126/science.298.5595.989. View

Heilmann J, Brun R, Mayr S, Rali T, Sticher O . Minor cytotoxic and antibacterial compounds from the rhizomes of Amomum aculeatum. Phytochemistry. 2001; 57(8):1281-5. DOI: 10.1016/s0031-9422(01)00174-1. View

Singh S, Kate B, Banerjee U . Bioactive compounds from cyanobacteria and microalgae: an overview. Crit Rev Biotechnol. 2005; 25(3):73-95. DOI: 10.1080/07388550500248498. View

Ortholand J, Ganesan A . Natural products and combinatorial chemistry: back to the future. Curr Opin Chem Biol. 2004; 8(3):271-80. DOI: 10.1016/j.cbpa.2004.04.011. View

Bordeleau M, Robert F, Gerard B, Lindqvist L, Chen S, Wendel H . Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model. J Clin Invest. 2008; 118(7):2651-60. PMC: 2423864. DOI: 10.1172/JCI34753. View

Balunas M, Jones W, Chin Y, Mi Q, Farnsworth N, Soejarto D . Relationships between inhibitory activity against a cancer cell line panel, profiles of plants collected, and compound classes isolated in an anticancer drug discovery project. Chem Biodivers. 2006; 3(8):897-915. DOI: 10.1002/cbdv.200690092. View

10.

Gerard B, Cencic R, Pelletier J, Porco Jr J . Enantioselective synthesis of the complex rocaglate (-)-silvestrol. Angew Chem Int Ed Engl. 2007; 46(41):7831-4. DOI: 10.1002/anie.200702707. View

11.

Feher M, Schmidt J . Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry. J Chem Inf Comput Sci. 2003; 43(1):218-27. DOI: 10.1021/ci0200467. View

12.

Workman P . New drug targets for genomic cancer therapy: successes, limitations, opportunities and future challenges. Curr Cancer Drug Targets. 2002; 1(1):33-47. DOI: 10.2174/1568009013334269. View

13.

Bohnenstengel F, Steube K, Meyer C, Quentmeier H, Nugroho B, Proksch P . 1H-cyclopenta[b]benzofuran lignans from Aglaia species inhibit cell proliferation and alter cell cycle distribution in human monocytic leukemia cell lines. Z Naturforsch C J Biosci. 2000; 54(12):1075-83. DOI: 10.1515/znc-1999-1212. View

14.

Kleer C, Cao Q, Varambally S, Shen R, Ota I, Tomlins S . EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci U S A. 2003; 100(20):11606-11. PMC: 208805. DOI: 10.1073/pnas.1933744100. View

15.

Nowak G . Protein kinase C-alpha and ERK1/2 mediate mitochondrial dysfunction, decreases in active Na+ transport, and cisplatin-induced apoptosis in renal cells. J Biol Chem. 2002; 277(45):43377-88. PMC: 1948818. DOI: 10.1074/jbc.M206373200. View

16.

Rose W, Crosswell A, Schurig J, CASAZZA A . Preclinical antitumor activity of orally administered platinum (IV) complexes. Cancer Chemother Pharmacol. 1993; 32(3):197-203. DOI: 10.1007/BF00685835. View

17.

Sulkowska-Ziaja K, Muszynska B, Konska G . Biologically active compounds of fungal origin displaying antitumor activity. Acta Pol Pharm. 2005; 62(2):153-9. View

18.

Kautz R, Goetzinger W, Karger B . High-throughput microcoil NMR of compound libraries using zero-dispersion segmented flow analysis. J Comb Chem. 2005; 7(1):14-20. DOI: 10.1021/cc0498940. View

19.

Salim A, Chai H, Rachman I, Riswan S, Kardono L, Farnsworth N . Constituents of the Leaves and Stem Bark of Aglaia foveolata. Tetrahedron. 2008; 63(33):7926-7934. PMC: 2034361. DOI: 10.1016/j.tet.2007.05.074. View

20.

Phifer S, Lee D, Seo E, Kim N, Graf T, Kroll D . Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitiensis. J Nat Prod. 2007; 70(6):954-61. PMC: 2442713. DOI: 10.1021/np070005a. View