Type 2 Diabetes, Polycystic Ovary Syndrome and the Insulin Resistance Syndrome in Adolescents: Are They One Big Iceberg?

Overview

Journal Paediatr Child Health

Publisher Oxford University Press

Specialty Pediatrics

Date 2010 Jan 5

PMID 20046314

Citations 1

Authors

Heather J Dean

Elizabeth Ac Sellers

Affiliations

Soon will be listed here.

Abstract

Obesity in children may cause overt clinical disease in childhood. The complex endocrine and metabolic changes of obesity and insulin resistance in adolescents result in hyperinsulinemia, dyslipidemia, hypertension, steatohepatitis, glucose intolerance, type 2 diabetes, acanthosis nigricans and ovarian hyperandrogenemia, commonly known as polycystic ovarian syndrome (PCOS). Type 2 diabetes and PCOS in adolescents are new endocrine diseases in this age group that require unique approaches to diagnosis and treatment. The direct correlation between duration of disease and control of the disease, and subsequent long term complications of these two diseases, predict serious morbidity in young adult life for the affected adolescents. Pediatricians have an important role in the prevention, diagnosis and treatment of obesity, insulin resistance syndrome, type 2 diabetes and PCOS.

Citing Articles

Circulating Adipokine Levels in Nonobese Women With Polycystic Ovary Syndrome and in Nonobese Control Women: A Systematic Review and Meta-Analysis.

Lin K, Sun X, Wang X, Wang H, Chen X Front Endocrinol (Lausanne). 2021; 11:537809.

PMID: 33488512 PMC: 7817813. DOI: 10.3389/fendo.2020.537809.

References

Freemark M, Bursey D . The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes. Pediatrics. 2001; 107(4):E55. DOI: 10.1542/peds.107.4.e55. View

Dietz W . Health consequences of obesity in youth: childhood predictors of adult disease. Pediatrics. 2002; 101(3 Pt 2):518-25. View

. Type 2 diabetes in children and adolescents. American Diabetes Association. Diabetes Care. 2000; 23(3):381-9. DOI: 10.2337/diacare.23.3.381. View

Fagot-Campagna A, Pettitt D, Engelgau M, Burrows N, Geiss L, Valdez R . Type 2 diabetes among North American children and adolescents: an epidemiologic review and a public health perspective. J Pediatr. 2000; 136(5):664-72. DOI: 10.1067/mpd.2000.105141. View

Dean H . NIDDM-Y in First Nation children in Canada. Clin Pediatr (Phila). 1998; 37(2):89-96. DOI: 10.1177/000992289803700205. View

SELLERS E, Dean H . Diabetic ketoacidosis: a complication of type 2 diabetes in Canadian aboriginal youth. Diabetes Care. 2000; 23(8):1202-4. DOI: 10.2337/diacare.23.8.1202. View

Kay J, Alemzadeh R, Langley G, DAngelo L, Smith P, Holshouser S . Beneficial effects of metformin in normoglycemic morbidly obese adolescents. Metabolism. 2001; 50(12):1457-61. DOI: 10.1053/meta.2001.28078. View

Dyck R, Klomp H, Tan L . From "thrifty genotype" to "hefty fetal phenotype": the relationship between high birthweight and diabetes in Saskatchewan Registered Indians. Can J Public Health. 2001; 92(5):340-4. PMC: 6979700. View

Sellers E, Eisenbarth G, Young T, Dean H . Diabetes-associated autoantibodies in aboriginal children. Lancet. 2000; 355(9210):1156. DOI: 10.1016/S0140-6736(00)02067-5. View

10.

Dean H . Dancing with many different ghosts: treatment of youth with type 2 diabetes. Diabetes Care. 2002; 25(1):237-8. DOI: 10.2337/diacare.25.1.237. View

11.

Dean H . Treatment of type 2 diabetes in youth: An argument for randomized controlled studies. Paediatr Child Health. 2010; 4(4):265-9. PMC: 2827719. DOI: 10.1093/pch/4.4.265. View

12.

Ibanez L, Valls C, Ferrer A, Marcos M, de Zegher F . Sensitization to insulin induces ovulation in nonobese adolescents with anovulatory hyperandrogenism. J Clin Endocrinol Metab. 2001; 86(8):3595-8. DOI: 10.1210/jcem.86.8.7756. View

13.

Franz M, Bantle J, Beebe C, Brunzell J, Chiasson J, Garg A . Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications. Diabetes Care. 2002; 25(1):148-98. DOI: 10.2337/diacare.25.1.148. View

14.

Gittelsohn J, Harris S, Burris K, Kakegamic L, Landman L, Sharma A . Use of ethnographic methods for applied research on diabetes among the Ojibway-Cree in northern Ontario. Health Educ Q. 1996; 23(3):365-82. DOI: 10.1177/109019819602300307. View

15.

Montgomery S, Ekbom A . Smoking during pregnancy and diabetes mellitus in a British longitudinal birth cohort. BMJ. 2002; 324(7328):26-7. PMC: 61655. DOI: 10.1136/bmj.324.7328.26. View

16.

Moghetti P, Castello R, Negri C, Tosi F, Perrone F, Caputo M . Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation. J Clin Endocrinol Metab. 2000; 85(1):139-46. DOI: 10.1210/jcem.85.1.6293. View

17.

Meltzer S, LEITER L, Daneman D, Gerstein H, Lau D, Ludwig S . 1998 clinical practice guidelines for the management of diabetes in Canada. Canadian Diabetes Association. CMAJ. 1998; 159 Suppl 8:S1-29. PMC: 1255890. View

18.

Jones K, Arslanian S, Peterokova V, Park J, Tomlinson M . Effect of metformin in pediatric patients with type 2 diabetes: a randomized controlled trial. Diabetes Care. 2002; 25(1):89-94. DOI: 10.2337/diacare.25.1.89. View

19.

Dabelea D, Hanson R, Lindsay R, Pettitt D, Imperatore G, Gabir M . Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships. Diabetes. 2000; 49(12):2208-11. DOI: 10.2337/diabetes.49.12.2208. View

20.

Dean H . Diagnostic criteria for non-insulin dependent diabetes in youth (NIDDM-Y). Clin Pediatr (Phila). 1998; 37(2):67-71. DOI: 10.1177/000992289803700202. View