Endothelial Progenitor Cells--an Evolving Story

Overview

Journal Microvasc Res

Specialty Cardiology & Vascular Diseases

Date 2010 Jan 2

PMID 20043930

Citations 29

Authors

Jeremy D Pearson

Affiliations

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Abstract

The first description of endothelial progenitor cells (EPC) in 1997 led rapidly to substantial changes in our understanding of angiogenesis, and within 5 years to the first clinical studies in humans using bone marrow derived EPC to enhance coronary neovascularisation and cardiac function after myocardial ischemia. However, to improve the success of this therapy a clearer understanding of the biology of EPC is needed. This article summarises recent data indicating that most EPC are not, in fact, endothelial progenitors but can be better described as angiogenic monocytes, and explores the implications this has for their future therapeutic use.

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