Genotypes Coding for Low Serum Levels of Mannose-binding Lectin Are Underrepresented Among Individuals Suffering from Noninfectious Systemic Inflammatory Response Syndrome

Overview

Journal Clin Vaccine Immunol

Publisher American Society for Microbiology

Specialties Allergy & Immunology
Pathology

Date 2010 Jan 1

PMID 20042521

Citations 5

Authors

Alex Smithson

Rafael Perello

Jesus Aibar

Gerard Espinosa

Dolors Tassies

Carolina Freire

Pedro Castro

Belen Suarez

Francisco Lozano

Josep-Maria Nicolas

Affiliations

Soon will be listed here.

Abstract

Gene polymorphisms, giving rise to low serum levels of mannose-binding lectin (MBL) or MBL-associated protease 2 (MASP2), have been associated with an increased risk of infections. The objective of this study was to assess the outcome of intensive care unit (ICU) patients with systemic inflammatory response syndrome (SIRS) regarding the existence of functionally relevant MBL2 and MASP2 gene polymorphisms. The study included 243 ICU patients with SIRS admitted to our hospital, as well as 104 healthy control subjects. MBL2 and MASP2 single nucleotide polymorphisms were genotyped using a sequence-based typing technique. No differences were observed regarding the frequencies of low-MBL genotypes (O/O and XA/O) and MASP2 polymorphisms between patients with SIRS and healthy controls. Interestingly, ICU patients with a noninfectious SIRS had a lower frequency for low-MBL genotypes and a higher frequency for high-MBL genotypes (A/A and A/XA) than either ICU patients with an infectious SIRS or healthy controls. The existence of low- or /high-MBL genotypes or a MASP2 polymorphism had no impact on the mortality rates of the included patients. The presence of high-MBL-producing genotypes in patients with a noninfectious insult is a risk factor for SIRS and ICU admission.

Citing Articles

Mannose-binding lectin-deficient genotypes as a risk factor of pneumococcal meningitis in infants.

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PMID: 28562692 PMC: 5451051. DOI: 10.1371/journal.pone.0178377.

Mannose-Binding Lectin Levels in Critically Ill Children With Severe Infections.

Madsen E, Levy E, Madden K, Agan A, Sullivan R, Graham D Pediatr Crit Care Med. 2016; 18(2):103-111.

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Su C, Lin Y, Cai L, Mao Q, Niu J Sci Rep. 2016; 6:32147.

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Activation of the lectin pathway of complement by cardiopulmonary bypass contributes to the development of systemic inflammatory response syndrome after paediatric cardiac surgery.

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Mannose-binding lectin polymorphisms and the risk of sepsis: evidence from a meta-analysis.

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