Chemokine Coreceptor Signaling in HIV-1 Infection and Pathogenesis

Overview

Journal PLoS Pathog

Specialty Microbiology

Date 2009 Dec 31

PMID 20041213

Citations 80

Authors

Yuntao Wu

Alyson Yoder

Affiliations

Soon will be listed here.

Abstract

Binding of the HIV-1 envelope to its chemokine coreceptors mediates two major biological events: membrane fusion and signaling transduction. The fusion process has been well studied, yet the role of chemokine coreceptor signaling in viral infection has remained elusive through the past decade. With the recent demonstration of the signaling requirement for HIV latent infection of resting CD4 T cells, the issue of coreceptor signaling needs to be thoroughly revisited. It is likely that virus-mediated signaling events may facilitate infection in various immunologic settings in vivo where cellular conditions need to be primed; in other words, HIV may exploit the chemokine signaling network shared among immune cells to gain access to downstream cellular components, which can then serve as effective tools to break cellular barriers. This virus-hijacked aberrant signaling process may in turn facilitate pathogenesis. In this review, we summarize past and present studies on HIV coreceptor signaling. We also discuss possible roles of coreceptor signaling in facilitating viral infection and pathogenesis.

Citing Articles

Characterization of a CXCR4 antagonist TIQ-15 with dual tropic HIV entry inhibition properties.

Zhou Z, Guo J, Hetrick B, Tiwari S, Haikerwal A, Han Y PLoS Pathog. 2024; 20(8):e1012448.

PMID: 39146384 PMC: 11349218. DOI: 10.1371/journal.ppat.1012448.

An immune-adrenergic pathway induces lethal levels of platelet-activating factor in mice.

Tanaka S, Kawakita M, Yasui H, Sudo K, Itoh F, Sasaki M Commun Biol. 2024; 7(1):782.

PMID: 38951147 PMC: 11217416. DOI: 10.1038/s42003-024-06498-7.

HIV-1 Structural Proteins or Cell-Signaling Factors? That Is the Question!.

Pellegrino M, Giordano F, De Amicis F, Marra M, Tucci P, Marsico S Curr Issues Mol Biol. 2024; 46(6):5100-5116.

PMID: 38920978 PMC: 11202448. DOI: 10.3390/cimb46060306.

The chemokine receptor CCR5: multi-faceted hook for HIV-1.

Faivre N, Verollet C, Dumas F Retrovirology. 2024; 21(1):2.

PMID: 38263120 PMC: 10807162. DOI: 10.1186/s12977-024-00634-1.

The Antiviral Compound PSP Inhibits HIV-1 Entry via PKR-Dependent Activation in Monocytic Cells.

Alvarez-Rivera E, Rodriguez-Valentin M, Boukli N Viruses. 2023; 15(3).

PMID: 36992512 PMC: 10051440. DOI: 10.3390/v15030804.

References

Vicente-Manzanares M, Cabrero J, Rey M, Perez-Martinez M, Ursa A, Itoh K . A role for the Rho-p160 Rho coiled-coil kinase axis in the chemokine stromal cell-derived factor-1alpha-induced lymphocyte actomyosin and microtubular organization and chemotaxis. J Immunol. 2001; 168(1):400-10. DOI: 10.4049/jimmunol.168.1.400. View

Eibert S, Lee K, Pipkorn R, Sester U, Wabnitz G, Giese T . Cofilin peptide homologs interfere with immunological synapse formation and T cell activation. Proc Natl Acad Sci U S A. 2004; 101(7):1957-62. PMC: 357034. DOI: 10.1073/pnas.0308282100. View

Derry J, Ochs H, Francke U . Isolation of a novel gene mutated in Wiskott-Aldrich syndrome. Cell. 1994; 78(4):635-44. DOI: 10.1016/0092-8674(94)90528-2. View

Mori K, Ringler D, Desrosiers R . Restricted replication of simian immunodeficiency virus strain 239 in macrophages is determined by env but is not due to restricted entry. J Virol. 1993; 67(5):2807-14. PMC: 237605. DOI: 10.1128/JVI.67.5.2807-2814.1993. View

Amara A, Gall S, Schwartz O, Salamero J, Montes M, Loetscher P . HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication. J Exp Med. 1997; 186(1):139-46. PMC: 2198965. DOI: 10.1084/jem.186.1.139. View

Chackerian B, Long E, Luciw P, Overbaugh J . Human immunodeficiency virus type 1 coreceptors participate in postentry stages in the virus replication cycle and function in simian immunodeficiency virus infection. J Virol. 1997; 71(5):3932-9. PMC: 191545. DOI: 10.1128/JVI.71.5.3932-3939.1997. View

Lee C, Liu Q, Tomkowicz B, Yi Y, Freedman B, Collman R . Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways. J Leukoc Biol. 2003; 74(5):676-82. DOI: 10.1189/jlb.0503206. View

Venkatachari N, Buchanan W, Ayyavoo V . Human immunodeficiency virus (HIV-1) infection selectively downregulates PD-1 expression in infected cells and protects the cells from early apoptosis in vitro and in vivo. Virology. 2008; 376(1):140-53. DOI: 10.1016/j.virol.2008.03.015. View

Masci A, Galgani M, Cassano S, De Simone S, Gallo A, De Rosa V . HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling. J Leukoc Biol. 2003; 74(6):1117-24. DOI: 10.1189/jlb.0503239. View

10.

Cicala C, Arthos J, Selig S, Dennis Jr G, Hosack D, Ryk D . HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication. Proc Natl Acad Sci U S A. 2002; 99(14):9380-5. PMC: 123149. DOI: 10.1073/pnas.142287999. View

11.

Banda N, Bernier J, Kurahara D, Kurrle R, Haigwood N, Sekaly R . Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis. J Exp Med. 1992; 176(4):1099-106. PMC: 2119378. DOI: 10.1084/jem.176.4.1099. View

12.

Lempicki R, Kovacs J, Baseler M, Adelsberger J, Dewar R, Natarajan V . Impact of HIV-1 infection and highly active antiretroviral therapy on the kinetics of CD4+ and CD8+ T cell turnover in HIV-infected patients. Proc Natl Acad Sci U S A. 2000; 97(25):13778-83. PMC: 17652. DOI: 10.1073/pnas.250472097. View

13.

Farzan M, Choe H, Martin K, Sun Y, Sidelko M, Mackay C . HIV-1 entry and macrophage inflammatory protein-1beta-mediated signaling are independent functions of the chemokine receptor CCR5. J Biol Chem. 1997; 272(11):6854-7. DOI: 10.1074/jbc.272.11.6854. View

14.

Alkhatib G, Combadiere C, Broder C, Feng Y, Kennedy P, Murphy P . CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science. 1996; 272(5270):1955-8. DOI: 10.1126/science.272.5270.1955. View

15.

Wong J, Hezareh M, Gunthard H, Havlir D, Ignacio C, Spina C . Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science. 1997; 278(5341):1291-5. DOI: 10.1126/science.278.5341.1291. View

16.

Ganju R, Brubaker S, Meyer J, Dutt P, Yang Y, Qin S . The alpha-chemokine, stromal cell-derived factor-1alpha, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways. J Biol Chem. 1998; 273(36):23169-75. DOI: 10.1074/jbc.273.36.23169. View

17.

Hellerstein M, Hanley M, Cesar D, Siler S, Papageorgopoulos C, Wieder E . Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans. Nat Med. 1999; 5(1):83-9. DOI: 10.1038/4772. View

18.

Arthos J, Rubbert A, Rabin R, Cicala C, Machado E, Wildt K . CCR5 signal transduction in macrophages by human immunodeficiency virus and simian immunodeficiency virus envelopes. J Virol. 2000; 74(14):6418-24. PMC: 112149. DOI: 10.1128/jvi.74.14.6418-6424.2000. View

19.

Fenyo E, Chiodi F, Lind B, von Gegerfelt A, Albert J, Olausson E . Distinct replicative and cytopathic characteristics of human immunodeficiency virus isolates. J Virol. 1988; 62(11):4414-9. PMC: 253886. DOI: 10.1128/JVI.62.11.4414-4419.1988. View

20.

Ashorn P, BERGER E, Moss B . Human immunodeficiency virus envelope glycoprotein/CD4-mediated fusion of nonprimate cells with human cells. J Virol. 1990; 64(5):2149-56. PMC: 249373. DOI: 10.1128/JVI.64.5.2149-2156.1990. View