Neopterin: Biomarker of Cell-mediated Immunity and Potent Usage As Biomarker in Silicosis and Other Occupational Diseases

Overview

Journal Indian J Occup Environ Med

Date 2009 Dec 31

PMID 20040967

Citations 22

Authors

Shubhangi K Pingle

Rajani G Tumane

Aruna A Jawade

Affiliations

Soon will be listed here.

Abstract

Neopterin is regarded as an early biomarker of the cellular immune response. This low molecular mass compound belongs to the class of pteridine and is a metabolite of guanosine triphosphate, which is produced by the activated macrophages and dendritic cells after stimulation with gamma-interferon. An international group acknowledges the fact that the levels of serum neopterin can be used as a marker of the effect of exposure to silica and other occupational diseases. The determination of neopterin is an innovative tool for monitoring diseases associated with the activation of cell-mediated immunity.

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