The Association of Glomerular Filtration Rate and Erectile Dysfunction with Severity of Coronary Artery Disease in Patients Presenting with Chest Pain

Overview

Journal Int Urol Nephrol

Publisher Springer

Specialty Nephrology

Date 2009 Dec 30

PMID 20039124

Citations 4

Authors

Yalcin Solak

Hakan Akilli

Huseyin Atalay

Mehmet Kayrak

Hasan Gok

Suleyman Turk

Affiliations

Soon will be listed here.

Abstract

Background: The most common cause of death in patients with chronic kidney disease is cardiovascular. Coexistence of reduced estimated glomerular filtration rate (eGFR) and erectile dysfunction (ED) may predate severe underlying coronary artery disease (CAD). The aim of this study was to evaluate the predictive value of presence and severity of ED and reduced estimated eGFR in the risk stratification of CAD in patients with chest pain.

Methods: Two hundred and sixty-five consecutive male patients with chest pain were included. All patients underwent exercise stress test (EST), of whom those with positive EST underwent coronary angiography. eGFR was calculated and sexual health inventory for men (SHIM) form was applied to evaluate ED. The relation between SHIM scores, eGFR and the number of arteries with significant lesions was evaluated.

Results: Of the 265 male patients, 105 had positive EST while the remaining 160 patients had negative EST. ED was present in 62 patients (38.8%) in the EST (-) group and in 64 patients (61%) in the EST (+) group (P = 0.000). In the EST (+) group, coronary angiography (CAG) revealed normal coronary anatomy or insignificant coronary lesions in 19 (18%), one-vessel disease in 45 (43%), two-vessel disease in 22 (21%) and three-vessel disease in 19 (18%) patients, respectively. The lowest ED prevalence (36.8%) was seen in patients who had normal coronary anatomy or insignificant coronary lesions while the highest prevalence was in those with three-vessel disease (89.5%). When eGFR were taken into account, there was a significant difference between the groups as well (107.2 ± 19.2 ml/min in the EST (-) group versus 94.1 ± 20.0 ml/min in the EST (+) group; P = 0.001).

Conclusion: The presence and severity of ED and reduced eGFR are associated with the severity of underlying CAD in patients presenting with chest pain, and they could be implemented in the risk stratification of these patients.

Citing Articles

Stage effect of chronic kidney disease in erectile function.

Costa M, Ponciano V, Costa T, Gomes C, Oliveira E Int Braz J Urol. 2017; 44(1):132-140.

PMID: 29064656 PMC: 5815543. DOI: 10.1590/S1677-5538.IBJU.2017.0228.

Association between renal function, erectile function and coronary artery disease: detection with coronary angiography.

Canat L, Canat M, Guner B, Gurbuz C, Caskurlu T Korean J Urol. 2015; 56(1):76-81.

PMID: 25598940 PMC: 4294859. DOI: 10.4111/kju.2015.56.1.76.

Uric acid level and erectile dysfunction in patients with coronary artery disease.

Solak Y, Akilli H, Kayrak M, Aribas A, Gaipov A, Turk S J Sex Med. 2014; 11(1):165-72.

PMID: 24433559 PMC: 3962193. DOI: 10.1111/jsm.12332.

Glomerular filtration rate is related to severity of obstructive coronary artery disease in patients undergoing coronary angiography.

Davoodi G, Mehrabi Pari S, Rezvanfard M, Fathollahi M, Amini M, Hakki E Int Urol Nephrol. 2011; 44(4):1161-8.

PMID: 22002110 DOI: 10.1007/s11255-011-0070-3.

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