Histopathology of the Tubuli Recti at the Start of Experimental Autoimmune Orchitis in Mice

Overview

Journal Med Mol Morphol

Publisher Springer

Specialties Cell Biology
Molecular Biology
Pathology

Date 2009 Dec 25

PMID 20033369

Citations 5

Authors

Munekazu Naito

Hayato Terayama

Shuichi Hirai

Ning Qu

Shinichi Kawata

Masahiro Itoh

Affiliations

Soon will be listed here.

Abstract

We previously established an experimental model of autoimmune orchitis (EAO) by means of immunization with testicular germ cells (TGC) alone in mice and confirmed that the disease can be transferred to mice that had received CD4+ but not CD8+ or B lymphocytes obtained from TGC-immunized donor mice. The tubuli recti (TR) are special in that lymphocytes first accumulate around them before spreading to the peripheral seminiferous tubules in EAO. However, the minute changes in the TR remain unknown. Therefore, we investigated the histopathology of the TR before the induction of spermatogenic disturbance. The results revealed that the first infiltrating lymphocytes around the TR were not only of T-cell but also of B-cell lineage. Moreover, it was also shown that some of these infiltrating lymphocytes migrated into the TR, with resultant degeneration of the TR epithelium before damage to the seminiferous epithelium. These findings indicate that TR epithelial cells are the first targets of autoreactive T and B lymphocytes in EAO.

Citing Articles

The Terminal Segment of the Seminiferous Tubule: The Current Discovery of Its Morphofunctional Importance in Mammals.

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Microenvironment for spermatogenesis and sperm maturation.

Miyaso H, Ogawa Y, Itoh M Histochem Cell Biol. 2022; 157(3):273-285.

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Contribution of IL-12/IL-35 common subunit p35 to maintaining the testicular immune privilege.

Terayama H, Yoshimoto T, Hirai S, Naito M, Qu N, Hatayama N PLoS One. 2014; 9(4):e96120.

PMID: 24760014 PMC: 3997559. DOI: 10.1371/journal.pone.0096120.

Orchestrated leukocyte recruitment to immune-privileged sites: absolute barriers versus educational gates.

Shechter R, London A, Schwartz M Nat Rev Immunol. 2013; 13(3):206-18.

PMID: 23435332 DOI: 10.1038/nri3391.

Experimental autoimmune orchitis as a model of immunological male infertility.

Naito M, Terayama H, Hirai S, Qu N, Lustig L, Itoh M Med Mol Morphol. 2012; 45(4):185-9.

PMID: 23224596 DOI: 10.1007/s00795-012-0587-2.

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