Effect of Age and Pregnancy on the Antibody and Cell-mediated Immune Responses of Horses to Equine Herpesvirus 1

Overview

Journal Can J Comp Med

Specialty Veterinary Medicine

Date 1977 Oct 1

PMID 200320

Citations 3

Authors

J D Gerber

A E Marron

E P BASS

W H BECKENHAUER

Affiliations

Soon will be listed here.

Abstract

The cell-mediated immune response and antibody response of horses of varying ages and of pregnant horses to equine herpesvirus 1 antigen were examined. Six to eight month old horses showed either no increase or slight increases in anti-equine herpesvirus 1 serum neutralizing antibody following vaccination and revaccination with a modified live equine herpesvirus 1 vaccine. However, these same horses showed a marked increase in the cell-mediated immune response to equine herpesvirus 1 as measured by the lymphocyte transformation test. Eighteen to 21 month old horses showed four to 64-fold increases in anti-equine herpesvirus 1 serum neutralizing antibody titer following vaccination, but the cell-mediated immune response to equine herpesvirus 1 was low or absent. Only after revaccination did they show an increased cell-mediated immune response to equine herpesvirus 1. The cell-mediated immune response of mares in the latter stages of pregnancy to equine herpesivurs 1 was suppressed although antibody titers increased as much as 16-fold following exposure to virulent equine herpesvirus 1.

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References

DOLL E, Bryans J . Immunization of young horses against viral rhinopneumonitis. Cornell Vet. 1963; 53:24-41. View

DOLL E, Bryans J . Epizootiology of equine viral rhinopneumonitis. J Am Vet Med Assoc. 1963; 142:31-7. View

DOLL E, McCollum W, Wallace M, Bryans J, Richards M . Complement-fixation reactions in equine virus abortion. Am J Vet Res. 1953; 14(50):40-5. View

Wilks C . In vitro cytotoxicity of serum and peripheral blood leukocytes for equine herpesvirus type 1-infected target cells. Am J Vet Res. 1977; 38(1):117-21. View

Rotter V, Schlesinger M, Kalderon R, Trainin N . Response of human lymphocytes to PHA and Con A, dependent on and regulated by THF, a thymic hormone. J Immunol. 1976; 117(5 Pt.2):1927-32. View

GERSHON R, Cohen P, Hencin R, Liebhaber S . Suppressor T cells. J Immunol. 1972; 108(3):586-90. View

Notkins A . Immune mechanisms by which the spread of viral infections is stopped. Cell Immunol. 1974; 11(1-3):478-83. DOI: 10.1016/0008-8749(74)90045-8. View

Jackson T, KENDRICK J . Paralysis of horses associated with equine herpesvirus 1 infection. J Am Vet Med Assoc. 1971; 158(8):1351-7. View

Bryans J . On immunity to disease caused by equine herpesvirus 1. J Am Vet Med Assoc. 1969; 155(2):294-300. View

10.

Thong Y, Steele R, VINCENT M, Hensen S, Bellanti J . Impaired in vitro cell-mediated immunity to rubella virus during pregnancy. N Engl J Med. 1973; 289(12):604-6. DOI: 10.1056/NEJM197309202891203. View

11.

Waksman B, Namba Y . On soluble mediators of immunologic regulation. Cell Immunol. 1976; 21(1):161-76. DOI: 10.1016/0008-8749(76)90337-3. View

12.

Eardley D, Sercarz E . Modulation of help and suppression in a hapten-carrier system. J Immunol. 1976; 116(3):600-5. View

13.

Taussig M . Demonstration of suppressor T cells in a population of 'educated' T cells. Nature. 1974; 248(445):236-8. DOI: 10.1038/248236a0. View

14.

Mackaness G, Lagrange P, Miller T, Ishibashi T . Feedback inhibition of specifically sensitized lymphocytes. J Exp Med. 1974; 139(3):543-59. PMC: 2139549. DOI: 10.1084/jem.139.3.543. View

15.

Biesecker J, Fitch F, Rowley D, Stuart F . Passive antibody delays development of cell-mediated immunity in rats receiving renal allografts. Transplant Proc. 1973; 5(1):667-9. View

16.

Morton H, Hegh V, CLUNIE G . Immunosuppression detected in pregnant mice by rosette inhibition test. Nature. 1974; 249(456):459-60. DOI: 10.1038/249459a0. View

17.

MILLAR K, Mills P, Baines M . A study of the influence of pregnancy on the thymus gland of the mouse. Am J Obstet Gynecol. 1973; 117(7):913-8. DOI: 10.1016/0002-9378(73)90061-6. View

18.

Wilks C, COGGINS L . Immunity to equine herpesvirus type 1 (rhinopneumonitis): in vitro lymphocyte response. Am J Vet Res. 1976; 37(5):486-92. View

19.

Finn R, St Hill C, Govan A, Ralfs I, Gurney F, Denye V . Immunological responses in pregnancy and survival of fetal homograft. Br Med J. 1972; 3(5819):150-2. PMC: 1788602. DOI: 10.1136/bmj.3.5819.150. View

20.

Hand T, CEGLOWSKI W, Damrongsak D, Friedman H . Development of antibody-forming cells in neonatal mice: stimulation and inhibition by calf thymus fractions. J Immunol. 1970; 105(2):442-50. View