Mechanics of Cytokinesis in Eukaryotes

Overview

Journal Curr Opin Cell Biol

Publisher Elsevier

Specialty Cell Biology

Date 2009 Dec 25

PMID 20031383

Citations 159

Authors

Thomas D Pollard

Affiliations

Soon will be listed here.

Abstract

Research on eukaryotic cytokinesis using advantageous model systems is rapidly advancing our understanding of most aspects of the process. Cytokinesis is very complicated with more than 100 proteins participating. Both fungi and animal cells use proteins to mark the cleavage site for the assembly of a contractile ring of actin filaments and myosin-II. Formins nucleate and elongate the actin filaments and myosin-II helps to organize the filaments into a contractile ring. Much is still to be learned about the organization of the contractile ring and the mechanisms that disassemble the ring as it constricts. Although fungi and animals share many proteins that contribute to cytokinesis, the extent to which they share mechanisms for the location, assembly, constriction, and disassembly of their contractile rings is still in question.

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