The Potential for Xanthine Oxidase Inhibition in the Prevention and Treatment of Cardiovascular and Cerebrovascular Disease

Overview

Journal Cardiovasc Psychiatry Neurol

Specialty Cardiology & Vascular Diseases

Date 2009 Dec 24

PMID 20029618

Citations 14

Authors

Peter Higgins

Jesse Dawson

Matthew Walters

Affiliations

Soon will be listed here.

Abstract

There is a now a wealth of epidemiological, animal, and clinical data to suggest the benefits of uric acid reduction and hxanthine oxidase inhibition in prevention of vascular disease. This review discusses the available epidemiological, preclinical, and clinical data and considers arguments for and against a role for serum uric acid in common cardiovascular disorders. It concludes that large scale trials with clinical endpoints are justified to address this important question and to define whether use of drugs such as allopurinol should be a routine part of preventative strategies.

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