Redox Regulation of Stem Cell Mobilization
Overview
Physiology
Affiliations
A growing body of evidence supports the role of redox signaling in the mechanisms of hematopoietic stem cell mobilization and homing. Cytokines and adhesion molecules control stem cell mobilization through a redox-regulated process. The FoxO-SirT network appears to be intimately involved in redox-regulated stem cell homeostasis, whereas the process of stem cell differentiation is regulated by redox effector factor-1 (Ref-1) protein. Lack of oxygen (hypoxia), specifically controlled hypoxia, can stimulate the growth of the stem cells in their niche, and hypoxia-inducible factor (HIF)-1alpha appears to play a significant role in their maintenance and homing mechanism.
Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil.
Huang X, Trinh T, Aljoufi A, Broxmeyer H Curr Stem Cell Rep. 2019; 4(2):149-157.
PMID: 31275803 PMC: 6605067. DOI: 10.1007/s40778-018-0127-7.
First steps to define murine amniotic fluid stem cell microenvironment.
Bertin E, Piccoli M, Franzin C, Spiro G, Dona S, Dedja A Sci Rep. 2016; 6:37080.
PMID: 27845396 PMC: 5109045. DOI: 10.1038/srep37080.
Assi R, Foster T, He H, Stamati K, Bai H, Huang Y Regen Med. 2016; 11(3):245-60.
PMID: 26986810 PMC: 4976993. DOI: 10.2217/rme-2015-0045.
MiR-17 partly promotes hematopoietic cell expansion through augmenting HIF-1α in osteoblasts.
Yang Y, Ma W, Wu D, Huang Y, Li H, Zou J PLoS One. 2013; 8(7):e70232.
PMID: 23936170 PMC: 3723828. DOI: 10.1371/journal.pone.0070232.
The nucleotide sugar UDP-glucose mobilizes long-term repopulating primitive hematopoietic cells.
Kook S, Cho J, Lee S, Lee B J Clin Invest. 2013; 123(8):3420-35.
PMID: 23863713 PMC: 3726149. DOI: 10.1172/JCI64060.