Experimental Evidence on the Immunopathogenesis of Primary Biliary Cirrhosis

Overview

Journal Cell Mol Immunol

Date 2009 Dec 24

PMID 20029462

Citations 24

Authors

Carlo Selmi

Francesca Meda

Anaid Kasangian

Pietro Invernizzi

Zhigang Tian

Zhexiong Lian

Mauro Podda

M Eric Gershwin

Affiliations

Soon will be listed here.

Abstract

Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease for which an autoimmune pathogenesis is supported by clinical and experimental data, including the presence of autoantibodies and autoreactive T cells. The etiology remains to be determined, yet data suggest that both a susceptible genetic background and unknown environmental factors determine disease onset. Multiple infectious and chemical candidates have been proposed to trigger the disease in a genetically susceptible host, mostly by molecular mimicry. Most recently, several murine models have been reported, including genetically determined models as well as models induced by immunization with xenobiotics and bacteria.

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