Pairing Computation with Experimentation: a Powerful Coupling for Understanding T Cell Signalling

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2009 Dec 24

PMID 20029448

Citations 27

Authors

Arup K Chakraborty

Jayajit Das

Affiliations

Soon will be listed here.

Abstract

T cells are activated when extracellular stimuli, such as a ligand binding to the T cell receptor, are converted into functional outputs by the T cell signalling network. T cell receptor signalling is a highly complex, stochastic and dynamic process involving many interacting proteins. This complexity often confounds intuition, making it difficult to develop mechanistic principles that underly experimental observations. In this Review, we describe how computational approaches can partner successfully with biological experimentation to help address this challenge, and we illustrate this paradigm by summarizing recent work that shows new aspects of the T cell signalling network.

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