Regulation of MRNA Cap Methylation

Overview

Journal Biochem J

Specialty Biochemistry

Date 2009 Dec 23

PMID 20025612

Citations 109

Authors

Victoria H Cowling

Affiliations

Soon will be listed here.

Abstract

The 7-methylguanosine cap added to the 5' end of mRNA is essential for efficient gene expression and cell viability. Methylation of the guanosine cap is necessary for the translation of most cellular mRNAs in all eukaryotic organisms in which it has been investigated. In some experimental systems, cap methylation has also been demonstrated to promote transcription, splicing, polyadenylation and nuclear export of mRNA. The present review discusses how the 7-methylguanosine cap is synthesized by cellular enzymes, the impact that the 7-methylguanosine cap has on biological processes, and how the mRNA cap methylation reaction is regulated.

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