Total Synthesis of a Library of Designed Hybrids of the Microtubule-stabilising Anticancer Agents Taxol, Discodermolide and Dictyostatin

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2009 Dec 22

PMID 20024345

Citations 11

Authors

Ian Paterson

Guy J Naylor

Takeshi Fujita

Esther Guzman

Amy E Wright

Affiliations

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Abstract

A hybrid library of the marine natural products dictyostatin and discodermolide, incorporating the taxol or taxotere side chains, were synthesised; preliminary biological evaluation in the PANC-1 cancer cell line revealed significant antiproliferative activity, demonstrating that a macrolide scaffold is an effective surrogate for the baccatin core of taxol.

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