Integration Column: Microfluidic High-throughput Screening
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Biology has always been a heavily technology limited field. Burgeoning fields such as systems biology require the development and implementation of new technologies, enabling high-throughput and high-fidelity measurements of large systems. Microfluidics promises to fulfil many of the requirements put forth. Here I will discuss the various approaches employed to date for performing high-throughput screening experiments on-chip, encompassing biochemical, biophysical, and cell-based assays.
Programmable Droplet Microfluidics Based on Machine Learning and Acoustic Manipulation.
Yiannacou K, Sharma V, Sariola V Langmuir. 2022; 38(38):11557-11564.
PMID: 36099548 PMC: 9520974. DOI: 10.1021/acs.langmuir.2c01061.
Fabrication approaches for high-throughput and biomimetic disease modeling.
Grubb M, Caliari S Acta Biomater. 2021; 132:52-82.
PMID: 33716174 PMC: 8433272. DOI: 10.1016/j.actbio.2021.03.006.
Hwang S, Gonzalez-Suarez A, Stybayeva G, Revzin A Clin Exp Otorhinolaryngol. 2020; 14(1):29-42.
PMID: 32772034 PMC: 7904428. DOI: 10.21053/ceo.2020.00626.
Long-term single cell analysis of S. pombe on a microfluidic microchemostat array.
Nobs J, Maerkl S PLoS One. 2014; 9(4):e93466.
PMID: 24710337 PMC: 3977849. DOI: 10.1371/journal.pone.0093466.
Convergence in parameters and predictions using computational experimental design.
Hagen D, White J, Tidor B Interface Focus. 2014; 3(4):20130008.
PMID: 24511374 PMC: 3915829. DOI: 10.1098/rsfs.2013.0008.