Global Signatures of Protein and MRNA Expression Levels

Overview

Journal Mol Biosyst

Publisher Royal Society of Chemistry

Specialties Biochemistry
Molecular Biology

Date 2009 Dec 22

PMID 20023718

Citations 607

Authors

Raquel de Sousa Abreu

Luiz O Penalva

Edward M Marcotte

Christine Vogel

Affiliations

Soon will be listed here.

Abstract

Cellular states are determined by differential expression of the cell's proteins. The relationship between protein and mRNA expression levels informs about the combined outcomes of translation and protein degradation which are, in addition to transcription and mRNA stability, essential contributors to gene expression regulation. This review summarizes the state of knowledge about large-scale measurements of absolute protein and mRNA expression levels, and the degree of correlation between the two parameters. We summarize the information that can be derived from comparison of protein and mRNA expression levels and discuss how corresponding sequence characteristics suggest modes of regulation.

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