New-onset Acute Interstitial Lung Disease After Treatment with Erlotinib in a Patient with Metastatic Squamous Cell Carcinoma of the Lung
Overview
Affiliations
Erlotinib is a Human Epidermal Growth Factor Receptor Type 1/tyrosine kinase (EGFR) inhibitor, which is used for non-small-cell lung cancer treatment. Erlotinib usually has a favorable safety profile however; adverse events such as interstitial lung disease (ILD) have been reported in pivotal studies. ILD usually occurs weeks to months after initiating therapy with Erlotinib. We report a case of Erlotinib induced ILD presenting within 5 days of initiating treatment with Erlotinib.
Transforming growth factor alpha is a critical mediator of radiation lung injury.
Chung E, Hudak K, Horton J, White A, Scroggins B, Vaswani S Radiat Res. 2014; 182(3):350-62.
PMID: 25117621 PMC: 4169125. DOI: 10.1667/RR13625.1.