Effects of Blockade of Dopamine D2 Receptors on Extracellular Citrulline Levels in the Nucleus Accumbens During Performance of a Conditioned Reflex Fear Response

Overview

Journal Neurosci Behav Physiol

Publisher Springer

Date 2009 Dec 17

PMID 20012493

Citations 2

Authors

N B Saulskaya

N V Fofonova

P V Sudorgina

Affiliations

Soon will be listed here.

Abstract

Vital microdialysis studies on Sprague-Dawley rats using HPLC showed that performance of a conditioned reflex fear response was accompanied by an increase in the extracellular level of citrulline (a coproduct of nitric oxide synthesis) in the nucleus accumbens. Administration of the dopamine D(2) receptor antagonist raclopride (10 microM) into the nucleus accumbens decreased the magnitude of the increase in the extracellular citrulline level in this structure during performance of the conditioned reflex fear response but had no effect on its behavioral measures (the level of freezing). Doses increased investigative activity in a novel context which had been inhibited by acquisition of the conditioned reflex fear response, without affecting the investigative behavior of control animals. These data suggest that the dopaminergic input and dopamine D(2) receptors control the activity of the NO-ergic system of the nucleus accumbens during performance of the conditioned reflex fear response and may control "transfer" of fear to another behavioral situation.

Citing Articles

Stimulating GABAergic Neurons in the Nucleus Accumbens Core Alters the Trigeminal Neuropathic Pain Responses in a Rat Model of Infraorbital Nerve Injury.

Islam J, Kc E, Kim S, Kim H, Park Y Int J Mol Sci. 2021; 22(16).

PMID: 34445124 PMC: 8395143. DOI: 10.3390/ijms22168421.

Access to the CNS: Biomarker Strategies for Dopaminergic Treatments.

van den Brink W, Palic S, Kohler I, de Lange E Pharm Res. 2018; 35(3):64.

PMID: 29450650 PMC: 5814527. DOI: 10.1007/s11095-017-2333-x.

References

Saulskaya N, Fofonova N . Effects of N-methyl-D-aspartate on extracellular citrulline level in the rat nucleus accumbens. Neurosci Lett. 2006; 407(1):91-5. DOI: 10.1016/j.neulet.2006.08.010. View

Savelev S . [Influence of local administration of apomorphine on citrulline extracellular level in the striatum: participation of the dopamine D1 and D2 receptors]. Ross Fiziol Zh Im I M Sechenova. 2005; 91(8):942-8. View

Heinemann T, Lan J, Pedersen V, Leblhuber F, Paulus W, Riederer P . Characterization and regional distribution of nitric oxide synthase in the human brain during normal ageing. Brain Res. 1999; 834(1-2):128-35. DOI: 10.1016/s0006-8993(99)01444-4. View

Kraus M, Prast H . Involvement of nitric oxide, cyclic GMP and phosphodiesterase 5 in excitatory amino acid and GABA release in the nucleus accumbens evoked by activation of the hippocampal fimbria. Neuroscience. 2002; 112(2):331-43. DOI: 10.1016/s0306-4522(02)00079-9. View

Saulskaia N, Mikhailova M . [Th effect of D2-dopamine receptor blockade on glutamate release into extracellular space of Nucleus accumbens during food reinforcement]. Zh Vyssh Nerv Deiat Im I P Pavlova. 2001; 51(2):254-5. View

Rescorla R . Spontaneous recovery. Learn Mem. 2004; 11(5):501-9. DOI: 10.1101/lm.77504. View

Strange P . Interesting times for dopamine receptors. Trends Neurosci. 1991; 14(2):43-5. DOI: 10.1016/0166-2236(91)90017-o. View

Garthwaite J . Glutamate, nitric oxide and cell-cell signalling in the nervous system. Trends Neurosci. 1991; 14(2):60-7. DOI: 10.1016/0166-2236(91)90022-m. View

Koo J, Han J, Kim J . Selective neurotoxic lesions of basolateral and central nuclei of the amygdala produce differential effects on fear conditioning. J Neurosci. 2004; 24(35):7654-62. PMC: 6729625. DOI: 10.1523/JNEUROSCI.1644-04.2004. View

10.

Gale G, Anagnostaras S, Godsil B, Mitchell S, Nozawa T, Sage J . Role of the basolateral amygdala in the storage of fear memories across the adult lifetime of rats. J Neurosci. 2004; 24(15):3810-5. PMC: 6729345. DOI: 10.1523/JNEUROSCI.4100-03.2004. View

11.

Bashkatova V, Kraus M, Vanin A, Hornick A, Philippu A, Prast H . 7-nitroindazole, nNOS inhibitor, attenuates amphetamine-induced amino acid release and nitric oxide generation but not lipid peroxidation in the rat brain. J Neural Transm (Vienna). 2004; 112(6):779-88. DOI: 10.1007/s00702-004-0224-x. View

12.

Savelev S, Saulskaia N . [Citrulline extracellular level in the nucleus accumbens during acquisition and extinction of classical conditioned fear response with pain reinforcement]. Zh Vyssh Nerv Deiat Im I P Pavlova. 2006; 56(1):86-94. View

13.

Milad M, Quirk G . Neurons in medial prefrontal cortex signal memory for fear extinction. Nature. 2002; 420(6911):70-4. DOI: 10.1038/nature01138. View

14.

Saulskaia N, Fofonova N, Savelev S . [Glutamatergic regulation of citrulline extracellular level in the nucleus accumbens during acquisition and expression of conditioned emotional response]. Ross Fiziol Zh Im I M Sechenova. 2007; 93(6):635-42. View

15.

Rescorla R . Pavlovian conditioning and its proper control procedures. Psychol Rev. 1967; 74(1):71-80. DOI: 10.1037/h0024109. View

16.

Bredt D, Hwang P, Snyder S . Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature. 1990; 347(6295):768-70. DOI: 10.1038/347768a0. View

17.

Goren M, Yurdun T, Uzbay I . Investigation of extracellular L-citrulline concentration in the striatum during alcohol withdrawal in rats. Neurochem Res. 2002; 26(12):1327-33. DOI: 10.1023/a:1014253618835. View

18.

Saulskaia N, Savelev S, Soloveva N, Fofonova N . [NO-synthase dependent increase in citrulline extracellular level in the nucleus accumbens during acquisition and expression of conditioned emotional response]. Ross Fiziol Zh Im I M Sechenova. 2006; 92(6):700-8. View

19.

Quirk G, Beer J . Prefrontal involvement in the regulation of emotion: convergence of rat and human studies. Curr Opin Neurobiol. 2006; 16(6):723-7. DOI: 10.1016/j.conb.2006.07.004. View

20.

Kawaguchi Y, Wilson C, Augood S, Emson P . Striatal interneurones: chemical, physiological and morphological characterization. Trends Neurosci. 1995; 18(12):527-35. DOI: 10.1016/0166-2236(95)98374-8. View