Accomplishments in 2008 in the Adjuvant Treatment of Rectal Cancer

Overview

Journal Gastrointest Cancer Res

Date 2009 Dec 17

PMID 20011572

Authors

Brian Czito

Florian Lordick

Affiliations

Soon will be listed here.

Abstract

Overview of the Disease IncidencePrognostic FactorsCurrent General Therapy Standards Surgery(Neo) Adjuvant Radiotherapy and ChemotherapyAccomplishments During the Year Time Duration Between Radiotherapy and SurgeryHistopathology Post-Neoadjuvant TherapyMetabolic Imaging During Neoadjuvant TherapyNew Drugs in Combination with RadiotherapyNew StrategiesFuture Strategies ControversiesComments on ResearchObstacles to Progress.

References

Wilks J, Liebig C, Tasleem S, Haderxhanaj K, Lee L, Farrow B . Rectal cancer patients benefit from implementation of a dedicated colorectal cancer center in a Veterans Affairs Medical Center. Am J Surg. 2009; 198(1):100-4. DOI: 10.1016/j.amjsurg.2008.09.020. View

Rodel C, Sauer R . Neoadjuvant radiotherapy and radiochemotherapy for rectal cancer. Recent Results Cancer Res. 2005; 165:221-30. DOI: 10.1007/3-540-27449-9_24. View

Quah H, Chou J, Gonen M, Shia J, Schrag D, Saltz L . Pathologic stage is most prognostic of disease-free survival in locally advanced rectal cancer patients after preoperative chemoradiation. Cancer. 2008; 113(1):57-64. DOI: 10.1002/cncr.23516. View

Beddy D, Hyland J, Winter D, Lim C, White A, Moriarty M . A simplified tumor regression grade correlates with survival in locally advanced rectal carcinoma treated with neoadjuvant chemoradiotherapy. Ann Surg Oncol. 2008; 15(12):3471-7. DOI: 10.1245/s10434-008-0149-y. View

Bujko K, Nowacki M, Nasierowska-Guttmejer A, Michalski W, Bebenek M, Kryj M . Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer. Br J Surg. 2006; 93(10):1215-23. DOI: 10.1002/bjs.5506. View

Rosenthal D, Catalano P, Haller D, Landry J, Sigurdson E, Spitz F . Phase I study of preoperative radiation therapy with concurrent infusional 5-fluorouracil and oxaliplatin followed by surgery and postoperative 5-fluorouracil plus leucovorin for T3/T4 rectal adenocarcinoma: ECOG E1297. Int J Radiat Oncol Biol Phys. 2008; 72(1):108-13. PMC: 4198328. DOI: 10.1016/j.ijrobp.2008.05.054. View

Kamangar F, Dores G, Anderson W . Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol. 2006; 24(14):2137-50. DOI: 10.1200/JCO.2005.05.2308. View

Quirke P, Durdey P, Dixon M, Williams N . Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological study of lateral tumour spread and surgical excision. Lancet. 1986; 2(8514):996-9. DOI: 10.1016/s0140-6736(86)92612-7. View

Kerr S, Norton S, Glynne-Jones R . Delaying surgery after neoadjuvant chemoradiotherapy for rectal cancer may reduce postoperative morbidity without compromising prognosis. Br J Surg. 2008; 95(12):1534-40. DOI: 10.1002/bjs.6377. View

10.

Kariv Y, Kariv R, Hammel J, Lavery I . Postoperative radiotherapy for stage IIIA rectal cancer: is it justified?. Dis Colon Rectum. 2008; 51(10):1459-66. DOI: 10.1007/s10350-008-9346-9. View

11.

Rosenberg R, Herrmann K, Gertler R, Kunzli B, Essler M, Lordick F . The predictive value of metabolic response to preoperative radiochemotherapy in locally advanced rectal cancer measured by PET/CT. Int J Colorectal Dis. 2008; 24(2):191-200. DOI: 10.1007/s00384-008-0616-8. View

12.

Sauer R, Becker H, Hohenberger W, Rodel C, Wittekind C, Fietkau R . Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med. 2004; 351(17):1731-40. DOI: 10.1056/NEJMoa040694. View

13.

Habr-Gama A, Perez R, Proscurshim I, Nunes Dos Santos R, Kiss D, Gama-Rodrigues J . Interval between surgery and neoadjuvant chemoradiation therapy for distal rectal cancer: does delayed surgery have an impact on outcome?. Int J Radiat Oncol Biol Phys. 2008; 71(4):1181-8. DOI: 10.1016/j.ijrobp.2007.11.035. View

14.

Capirci C, Valentini V, Cionini L, De Paoli A, Rodel C, Glynne-Jones R . Prognostic value of pathologic complete response after neoadjuvant therapy in locally advanced rectal cancer: long-term analysis of 566 ypCR patients. Int J Radiat Oncol Biol Phys. 2008; 72(1):99-107. DOI: 10.1016/j.ijrobp.2007.12.019. View

15.

Braendengen M, Tveit K, Berglund A, Birkemeyer E, Frykholm G, Pahlman L . Randomized phase III study comparing preoperative radiotherapy with chemoradiotherapy in nonresectable rectal cancer. J Clin Oncol. 2008; 26(22):3687-94. DOI: 10.1200/JCO.2007.15.3858. View

16.

Tulchinsky H, Shmueli E, Figer A, Klausner J, Rabau M . An interval >7 weeks between neoadjuvant therapy and surgery improves pathologic complete response and disease-free survival in patients with locally advanced rectal cancer. Ann Surg Oncol. 2008; 15(10):2661-7. DOI: 10.1245/s10434-008-9892-3. View

17.

Gunderson L, Callister M, Marschke R, Young-Fadok T, Heppell J, Efron J . Stratification of rectal cancer stage for selection of postoperative chemoradiotherapy: current status. Gastrointest Cancer Res. 2009; 2(1):25-33. PMC: 2630810. View

18.

Quirke P, Steele R, Monson J, Grieve R, Khanna S, Couture J . Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial. Lancet. 2009; 373(9666):821-8. PMC: 2668948. DOI: 10.1016/S0140-6736(09)60485-2. View

19.

Schmiegel W, Reinacher-Schick A, Arnold D, Graeven U, Heinemann V, Porschen R . [Update S3-guideline "colorectal cancer" 2008]. Z Gastroenterol. 2008; 46(8):799-840. DOI: 10.1055/s-2008-1027726. View

20.

Siegel R, Dresel S, Koswig S, Gebauer B, Hunerbein M, Schneider W . Response to preoperative short-course radiotherapy in locally advanced rectal cancer: value of f-fluorodeoxyglucose positron emission tomography. Onkologie. 2008; 31(4):166-72. DOI: 10.1159/000118037. View