Lack of Association Between Toll-like Receptor 4 Gene Polymorphisms and Sarcoidosis-related Uveitis in Japan

Overview

Journal Mol Vis

Specialties Cell Biology
Molecular Biology
Ophthalmology

Date 2009 Dec 17

PMID 20011079

Citations 7

Authors

Yuri Asukata

Masao Ota

Akira Meguro

Yoshihiko Katsuyama

Mami Ishihara

Kenichi Namba

Nobuyoshi Kitaichi

Shin-Ichiro Morimoto

Toshikatsu Kaburaki

Yasutaka Ando

Shinobu Takenaka

Hidetoshi Inoko

Shigeaki Ohno

Nobuhisa Mizuki

Affiliations

Soon will be listed here.

Abstract

Purpose: Toll-like receptors (TLRs) are pattern-recognition receptors that play an important role in innate and adaptive immune responses to microbial pathogens. Among TLRs, TLR4 recognizes lipopolysaccharides of Gram-negative bacteria. Genetic polymorphisms within the TLR4 gene have been reported to be associated with various inflammatory diseases; therefore, TLR4 appears to be a susceptibility gene for sarcoidosis. Although sarcoidosis has various clinical manifestations, its association with uveitis is more common in Japan than in other countries. The aim of this study was to investigate whether TLR4 polymorphisms were associated with sarcoidosis-related uveitis in a Japanese population.

Methods: Two hundred twenty-three patients with sarcoidosis and 206 healthy control subjects were recruited at seven sites in Japan. Eight single-nucleotide polymorphisms (SNPs) in TLR4 were genotyped with a TaqMan assay, and allelic and phenotypic diversity were assessed in affected and control subjects.

Results: We found no association with susceptibility to sarcoid-related uveitis for any of the SNPs analyzed. Strong linkage disequilibrium was observed among all the SNPs analyzed (D'>/=0.78), which were located in one haplotype block.

Conclusion: TLR4 polymorphisms do not play an important role in the development of uveitis in Japanese patients with sarcoidosis.

Citing Articles

Noninfectious uveitis in the Asia-Pacific region.

Hsu Y, Chien-Chieh Huang J, Tao Y, Kaburaki T, Lee C, Lin T Eye (Lond). 2018; 33(1):66-77.

PMID: 30323327 PMC: 6328561. DOI: 10.1038/s41433-018-0223-z.

Association of genetic variants in and with uveitis in sarcoidosis.

Davoudi S, Chang V, Navarro-Gomez D, Stanwyck L, Sevgi D, Papavasileiou E Mol Vis. 2018; 24:59-74.

PMID: 29416296 PMC: 5783744.

Induction of Pulmonary Granuloma Formation by Propionibacterium acnes Is Regulated by MyD88 and Nox2.

Werner J, Escolero S, Hewlett J, Mak T, Williams B, Eishi Y Am J Respir Cell Mol Biol. 2016; 56(1):121-130.

PMID: 27607191 PMC: 5248957. DOI: 10.1165/rcmb.2016-0035OC.

Sarcoidosis vs. Sarcoid-like reactions: The Two Sides of the same Coin?.

Tchernev G, Tana C, Schiavone C, Cardoso J, Ananiev J, Wollina U Wien Med Wochenschr. 2014; 164(13-14):247-59.

PMID: 24664574 DOI: 10.1007/s10354-014-0269-x.

Lack of association between IL10 polymorphisms and sarcoidosis in Japanese patients.

Sakuyama K, Meguro A, Ota M, Ishihara M, Uemoto R, Ito H Mol Vis. 2012; 18:512-8.

PMID: 22393278 PMC: 3291520.

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