Creating and Curing Fatty Hearts

Overview

Journal Curr Opin Clin Nutr Metab Care

Specialty General Medicine

Date 2009 Dec 17

PMID 20010095

Citations 18

Authors

Raffay S Khan

Konstaninos Drosatos

Ira J Goldberg

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: Diseases associated with ectopic disposition of lipids are becoming an increasingly important medical problem as the incidence of type 2 diabetes and obesity increases. One of the organs affected by lipotoxicity is the heart and this review presents an update on human and animal studies of this problem.

Recent Findings: Human studies have clearly correlated heart dysfunction with the content of triglyceride. More recently human heart samples have been used to assess gene changes associated with altered lipid accumulation. Genetically altered mice have been created that develop lipotoxic cardiomyopathies and newer investigations are attempting to delineate curative therapies.

Summary: Human studies will confirm the metabolic changes associated with lipotoxic cardiomyopathy and, hopefully, animal studies will guide treatment options.

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