Nuclear Networking Fashions Pre-messenger RNA and Primary MicroRNA Transcripts for Function

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 2009 Dec 17

PMID 20004579

Citations 39

Authors

Jan M Pawlicki

Joan A Steitz

Affiliations

Soon will be listed here.

Abstract

The expression of protein-coding genes is enhanced by the exquisite coupling of transcription by RNA polymerase II with pre-messenger RNA processing reactions, such as 5'-end capping, splicing and 3'-end formation. Integration between cotranscriptional processing events extends beyond the nucleus, as proteins that bind cotranscriptionally can affect the localization, translation and degradation of the mature messenger RNA. MicroRNAs are RNA polymerase II transcripts with crucial roles in the regulation of gene expression. Recent data demonstrate that processing of primary microRNA transcripts might be yet another cotranscriptional event that is woven into this elaborate nuclear network. This review discusses the extensive molecular interactions that couple the earliest steps in gene expression and therefore influence the final fate and function of the mature messenger RNA or microRNA produced.

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