Metabolic Reprogramming, Caloric Restriction and Aging

Overview

Journal Trends Endocrinol Metab

Specialty Endocrinology

Date 2009 Dec 17

PMID 20004110

Citations 133

Authors

Rozalyn M Anderson

Richard Weindruch

Affiliations

Soon will be listed here.

Abstract

Caloric restriction (CR) without malnutrition slows the aging process and extends lifespan in diverse species by unknown mechanisms. The inverse linear relationship between calorie intake and lifespan suggests that regulators of energy metabolism are important in the actions of CR. Studies in several species reveal tissue-specific changes in energy metabolism with CR and suggest that metabolic reprogramming plays a critical role in its mechanism of aging retardation. We herein describe common signatures of CR and suggest how they can slow aging. We discuss recent advances in understanding the function of key metabolic regulators that probably coordinate the response to altered nutrient availability with CR and how the pathways they regulate can retard the aging process.

Citing Articles

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