» Articles » PMID: 20003334

A Rare Case of Acute Lymphoblastic Leukaemia with Hemophilia A

Overview
Journal Ital J Pediatr
Publisher Biomed Central
Specialty Pediatrics
Date 2009 Dec 17
PMID 20003334
Citations 1
Authors
Affiliations
Soon will be listed here.
Abstract

A rare case of Acute lymphoblastic leukemia with hemophillia in a 12 year old boy is presented in the article. Patient was known case of hemophillia (factor VIII deficiency). He was diagnosed as a case of ALL based on bone marrow examination and immunophenotypic study. Patient was treated as per Children Cancer group guidelines. The main aim of reporting this rare association lies in developing treatment strategies in preventing life threatening bleeding due to this rare association which though may be accidental but need further research.

Citing Articles

Concurrent lymphoma and hemophilia B in a pediatric patient: A case report.

Lu G, Qiao L, Li D, Liu Z, Zhao F, Yu D Medicine (Baltimore). 2019; 98(19):e15474.

PMID: 31083180 PMC: 6531284. DOI: 10.1097/MD.0000000000015474.

References
1.
Madhok R, Gracie A, Lowe G, Burnett A, Froebel K, Follett E . Impaired cell mediated immunity in haemophilia in the absence of infection with human immunodeficiency virus. Br Med J (Clin Res Ed). 1986; 293(6553):978-80. PMC: 1341772. DOI: 10.1136/bmj.293.6553.978. View

2.
Rechavi G, Ben-Bassat I, Berkowicz M, Martinowitz U, Brok-Simoni F, Neumann Y . Molecular analysis of Burkitt's leukemia in two hemophilic brothers with AIDS. Blood. 1987; 70(6):1713-7. View

3.
Turner M, Watson H, Russell L, Langlands K, Ludlam C, Parker A . An HIV positive haemophiliac with acute lymphoblastic leukaemia successfully treated with intensive chemotherapy and syngeneic bone marrow transplantation. Bone Marrow Transplant. 1992; 9(5):387-9. View

4.
Kawakami K, Takezaki T, Nakazono S, Kitahara T, Ikarimoto N, Tanaka Y . Acute childhood leukemia in a patient with hemophilia: first report in Japan. Acta Paediatr Jpn. 1994; 36(1):91-4. DOI: 10.1111/j.1442-200x.1994.tb03138.x. View

5.
Zulfikar B . Two patients with haemophilia and acute leukaemia. Haemophilia. 2002; 8(5):698-702. DOI: 10.1046/j.1365-2516.2002.00660.x. View