Nutraceuticals and Prostate Cancer Prevention: a Current Review

Overview

Journal Nat Rev Urol

Specialty Urology

Date 2009 Dec 10

PMID 19997071

Citations 30

Authors

Greg Trottier

Peter J Bostrom

Nathan Lawrentschuk

Neil E Fleshner

Affiliations

Soon will be listed here.

Abstract

Nutraceuticals are 'natural' substances isolated or purified from food substances and used in a medicinal fashion. Several naturally derived food substances have been studied in prostate cancer in an attempt to identify natural preventative therapies for this disease. Vitamin E, selenium, vitamin D, green tea, soy, and lycopene have all been examined in human studies. Other potential nutraceuticals that lack human data, most notably pomegranate, might also have a preventative role in this disease. Unfortunately, most of the literature involving nutraceuticals in prostate cancer is epidemiological and retrospective. The paucity of randomized control trial evidence for the majority of these substances creates difficulty in making clinical recommendations particularly when most of the compounds have no evidence of toxicity and occur naturally. Despite these shortcomings, this area of prostate cancer prevention is still under intense investigation. We believe many of these 'natural' compounds have therapeutic potential and anticipate future studies will consist of well-designed clinical trials assessing combinations of compounds concurrently.

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References

Jatoi A, Burch P, Hillman D, Vanyo J, Dakhil S, Nikcevich D . A tomato-based, lycopene-containing intervention for androgen-independent prostate cancer: results of a Phase II study from the North Central Cancer Treatment Group. Urology. 2007; 69(2):289-94. DOI: 10.1016/j.urology.2006.10.019. View

Matlaga B, Hall M, Stindt D, Torti F . Response of hormone refractory prostate cancer to lycopene. J Urol. 2001; 166(2):613. View

Chan J, Stampfer M, Ma J, Rimm E, Willett W, Giovannucci E . Supplemental vitamin E intake and prostate cancer risk in a large cohort of men in the United States. Cancer Epidemiol Biomarkers Prev. 1999; 8(10):893-9. View

Syed D, Suh Y, Afaq F, Mukhtar H . Dietary agents for chemoprevention of prostate cancer. Cancer Lett. 2008; 265(2):167-76. PMC: 3220618. DOI: 10.1016/j.canlet.2008.02.050. View

John E, Schwartz G, Koo J, van den Berg D, Ingles S . Sun exposure, vitamin D receptor gene polymorphisms, and risk of advanced prostate cancer. Cancer Res. 2005; 65(12):5470-9. DOI: 10.1158/0008-5472.CAN-04-3134. View

Allen N, Sauvaget C, Roddam A, Appleby P, Nagano J, Suzuki G . A prospective study of diet and prostate cancer in Japanese men. Cancer Causes Control. 2004; 15(9):911-20. DOI: 10.1007/s10552-004-1683-y. View

Di Silverio F, La Pera G, Tenaglia R . Age-adjusted mortality rate and regional distribution for prostatic carcinoma in Italy between 1969 and 1978. Prostate. 1982; 3(6):631-6. DOI: 10.1002/pros.2990030613. View

Hanchette C, Schwartz G . Geographic patterns of prostate cancer mortality. Evidence for a protective effect of ultraviolet radiation. Cancer. 1992; 70(12):2861-9. DOI: 10.1002/1097-0142(19921215)70:12<2861::aid-cncr2820701224>3.0.co;2-g. View

John E, Dreon D, Koo J, Schwartz G . Residential sunlight exposure is associated with a decreased risk of prostate cancer. J Steroid Biochem Mol Biol. 2004; 89-90(1-5):549-52. DOI: 10.1016/j.jsbmb.2004.03.067. View

10.

Jatoi A, Ellison N, Burch P, Sloan J, Dakhil S, Novotny P . A phase II trial of green tea in the treatment of patients with androgen independent metastatic prostate carcinoma. Cancer. 2003; 97(6):1442-6. DOI: 10.1002/cncr.11200. View

11.

Choan E, Segal R, Jonker D, Malone S, Reaume N, Eapen L . A prospective clinical trial of green tea for hormone refractory prostate cancer: an evaluation of the complementary/alternative therapy approach. Urol Oncol. 2005; 23(2):108-13. DOI: 10.1016/j.urolonc.2004.10.008. View

12.

Kranse R, Dagnelie P, van Kemenade M, de Jong F, Blom J, Tijburg L . Dietary intervention in prostate cancer patients: PSA response in a randomized double-blind placebo-controlled study. Int J Cancer. 2004; 113(5):835-40. DOI: 10.1002/ijc.20653. View

13.

Hamilton R, Freedland S . Rationale for statins in the chemoprevention of prostate cancer. Curr Urol Rep. 2008; 9(3):189-96. DOI: 10.1007/s11934-008-0034-z. View

14.

Swami S, Krishnan A, Moreno J, Bhattacharyya R, Gardner C, Brooks J . Inhibition of prostaglandin synthesis and actions by genistein in human prostate cancer cells and by soy isoflavones in prostate cancer patients. Int J Cancer. 2009; 124(9):2050-9. PMC: 4777303. DOI: 10.1002/ijc.24161. View

15.

Schwartz G . Vitamin D and the epidemiology of prostate cancer. Semin Dial. 2005; 18(4):276-89. DOI: 10.1111/j.1525-139X.2005.18403.x. View

16.

Hamilton-Reeves J, Rebello S, Thomas W, Slaton J, Kurzer M . Soy protein isolate increases urinary estrogens and the ratio of 2:16alpha-hydroxyestrone in men at high risk of prostate cancer. J Nutr. 2007; 137(10):2258-63. DOI: 10.1093/jn/137.10.2258. View

17.

Dalais F, Meliala A, Wattanapenpaiboon N, Frydenberg M, Suter D, Thomson W . Effects of a diet rich in phytoestrogens on prostate-specific antigen and sex hormones in men diagnosed with prostate cancer. Urology. 2004; 64(3):510-5. DOI: 10.1016/j.urology.2004.04.009. View

18.

Bettuzzi S, Brausi M, Rizzi F, Castagnetti G, Peracchia G, Corti A . Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res. 2006; 66(2):1234-40. DOI: 10.1158/0008-5472.CAN-05-1145. View

19.

Mills P, Beeson W, Phillips R, Fraser G . Cohort study of diet, lifestyle, and prostate cancer in Adventist men. Cancer. 1989; 64(3):598-604. DOI: 10.1002/1097-0142(19890801)64:3<598::aid-cncr2820640306>3.0.co;2-6. View

20.

Jian L . Soy, isoflavones, and prostate cancer. Mol Nutr Food Res. 2008; 53(2):217-26. DOI: 10.1002/mnfr.200800167. View