Evidence for an Involvement of the Brain Cholecystokinin B Receptor in Anxiety

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1991 Feb 15

PMID 1996314

Citations 40

Authors

L Singh

A S Lewis

M J Field

J Hughes

G N Woodruff

Affiliations

Soon will be listed here.

Abstract

The effect of neuropeptide cholecystokinin (CCK) receptor agonists and antagonists was examined in the rat elevated X-maze model of anxiety. The selective CCK-B receptor antagonists CI-988 (PD 134308) and L-365,260 produced anxiolytic-like effects, whereas MK-329, a CCK-A receptor antagonist, was respectively less potent by factors of 313 and 200. The intracerebroventricular administration of the nonselective CCK receptor agonist caerulein or the selective CCK-B receptor agonist pentagastrin increased dose dependently the level of anxiety. CI-988 dose dependently antagonized the anxiogenic response to pentagastrin but not that induced by pentylenetetrazol. These results strongly suggest that activation of the brain CCK-B receptor induces anxiety and that selective antagonists of this receptor represent a separate class of anxiolytic agents.

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