Clinical Usefulness of Variable-frequency Ultrasound in Localized Lesions of the Skin

Background: High variable-frequency ultrasound is a recently available technique capable of clearly defining skin layers and deeper structures that also provides local perfusion patterns obtained in real time.

Objectives: The aim of the study was to assess the performance of variable-frequency ultrasound in the evaluation of skin lesions.

Methods: We performed a retrospective study of 4338 skin ultrasound examinations in predominantly localized skin lesions, and in a group of 130 healthy controls. We determined ultrasound sensitivity, specificity, and statistical level of certainty, and compared ultrasound diagnoses with clinical diagnoses.

Results: Referring diagnosis was correct in 73% of the lesions, and addition of ultrasound increased correctness to 97% (P < .001 for the difference). Ultrasound overall sensitivity was 99%, specificity was 100%, and statistical diagnostic certainty was 99%

Limitations: Ultrasound in its current version cannot detect lesions that are epidermal only or that measure less than 0.1 mm in depth.

Conclusions: Ultrasound is a reliable adjuvant for the accurate and precise diagnosis of skin lesions.