Recombination in Vaccine and Circulating Strains of Porcine Reproductive and Respiratory Syndrome Viruses

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2009 Dec 8

PMID 19961694

Citations 61

Authors

Bin Li

Liurong Fang

Zuofei Xu

Suyan Liu

Jianfeng Gao

Yunbo Jiang

Huanchun Chen

Shaobo Xiao

Affiliations

Soon will be listed here.

Abstract

Em2007, a porcine reproductive and respiratory syndrome virus (PRRSV) variant with a unique 68 aa deletion in Nsp2, was recently isolated in China. Phylogenetic and molecular evolutionary analyses indicated that Em2007 is a natural recombinant between a vaccine strain of PRRSV and circulating virus. We also tested its pathogenicity in piglets.

Citing Articles

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Current Status of Porcine Reproductive and Respiratory Syndrome Vaccines.

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Can self-amplifying RNA vaccines and viruses exchange genetic material?.

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Development, Evaluation, and Clinical Application of PRRSV-2 Vaccine-like Real-Time RT-PCR Assays.

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References

Tong G, Zhou Y, Hao X, Tian Z, An T, Qiu H . Highly pathogenic porcine reproductive and respiratory syndrome, China. Emerg Infect Dis. 2008; 13(9):1434-6. PMC: 2857295. DOI: 10.3201/eid1309.070399. View

Meulenberg J . PRRSV, the virus. Vet Res. 2000; 31(1):11-21. DOI: 10.1051/vetres:2000103. View

Tian K, Yu X, Zhao T, Feng Y, Cao Z, Wang C . Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark. PLoS One. 2007; 2(6):e526. PMC: 1885284. DOI: 10.1371/journal.pone.0000526. View

Gao Z, Guo X, Yang H . Genomic characterization of two Chinese isolates of porcine respiratory and reproductive syndrome virus. Arch Virol. 2004; 149(7):1341-51. DOI: 10.1007/s00705-004-0292-0. View

Feng Y, Zhao T, Nguyen T, Inui K, Ma Y, Nguyen T . Porcine respiratory and reproductive syndrome virus variants, Vietnam and China, 2007. Emerg Infect Dis. 2008; 14(11):1774-6. PMC: 2630730. DOI: 10.3201/eid1411.071676. View

Kapur V, Elam M, Pawlovich T, Murtaugh M . Genetic variation in porcine reproductive and respiratory syndrome virus isolates in the midwestern United States. J Gen Virol. 1996; 77 ( Pt 6):1271-6. DOI: 10.1099/0022-1317-77-6-1271. View

Fang Y, Kim D, Ropp S, Steen P, Christopher-Hennings J, Nelson E . Heterogeneity in Nsp2 of European-like porcine reproductive and respiratory syndrome viruses isolated in the United States. Virus Res. 2004; 100(2):229-35. DOI: 10.1016/j.virusres.2003.12.026. View

Allende R, Lewis T, Lu Z, Rock D, Kutish G, Ali A . North American and European porcine reproductive and respiratory syndrome viruses differ in non-structural protein coding regions. J Gen Virol. 1999; 80 ( Pt 2):307-315. DOI: 10.1099/0022-1317-80-2-307. View

Yuan S, Nelsen C, Murtaugh M, Schmitt B, Faaberg K . Recombination between North American strains of porcine reproductive and respiratory syndrome virus. Virus Res. 1999; 61(1):87-98. PMC: 7125646. DOI: 10.1016/s0168-1702(99)00029-5. View

10.

Han J, Wang Y, Faaberg K . Complete genome analysis of RFLP 184 isolates of porcine reproductive and respiratory syndrome virus. Virus Res. 2006; 122(1-2):175-82. DOI: 10.1016/j.virusres.2006.06.003. View

11.

Lole K, Bollinger R, Paranjape R, Gadkari D, Kulkarni S, Novak N . Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination. J Virol. 1998; 73(1):152-60. PMC: 103818. DOI: 10.1128/JVI.73.1.152-160.1999. View

12.

Kosakovsky Pond S, Posada D, Gravenor M, Woelk C, Frost S . Automated phylogenetic detection of recombination using a genetic algorithm. Mol Biol Evol. 2006; 23(10):1891-901. DOI: 10.1093/molbev/msl051. View