Multivitamin Supplement Use and Risk of Invasive Breast Cancer

Overview

Journal Public Health Nutr

Publisher Cambridge University Press

Date 2009 Dec 4

PMID 19954572

Citations 5

Authors

Johanna M Meulepas

Polly A Newcomb

Andrea N Burnett-Hartman

John M Hampton

Amy Trentham-Dietz

Affiliations

Soon will be listed here.

Abstract

Objective: Multivitamin supplements are used by nearly half of middle-aged women in the USA. Despite this high prevalence of multivitamin use, little is known about the effects of multivitamins on health outcomes, including cancer risk. Our main objective was to determine the association between multivitamin use and the risk of breast cancer in women.

Design: We conducted a population-based case-control study among 2968 incident breast cancer cases (aged 20-69 years), diagnosed between 2004 and 2007, and 2982 control women from Wisconsin, USA. All participants completed a structured telephone interview which ascertained supplement use prior to diagnosis, demographics and risk factor information. Odds ratios and 95 % confidence intervals were calculated using multivariable logistic regression.

Results: Compared with never users of multivitamins, the OR for breast cancer was 1.02 (95 % CI 0.87, 1.19) for current users and 0.99 (95 % CI 0.74, 1.33) for former users. Further, neither duration of use (for > or =10 years: OR = 1.13, 95 % CI 0.93, 1.38, P for trend = 0.25) nor frequency (>7 times/week: OR = 1.00, 95 % CI 0.77, 1.28, P for trend = 0.97) was related to risk in current users. Stratification by menopausal status, family history of breast cancer, age, alcohol, tumour staging and postmenopausal hormone use did not significantly modify the association between multivitamin use and breast cancer.

Conclusions: The current study found no association between multivitamin supplement use and breast cancer risk in women.

Citing Articles

Nutrition and Breast Cancer: A Literature Review on Prevention, Treatment and Recurrence.

De Cicco P, Catani M, Gasperi V, Sibilano M, Quaglietta M, Savini I Nutrients. 2019; 11(7).

PMID: 31277273 PMC: 6682953. DOI: 10.3390/nu11071514.

Phytotherapy and Nutritional Supplements on Breast Cancer.

Lopes C, Dourado A, Oliveira R Biomed Res Int. 2017; 2017:7207983.

PMID: 28845434 PMC: 5563402. DOI: 10.1155/2017/7207983.

Breast Cancer and DNA Repair Capacity: Association With Use of Multivitamin and Calcium Supplements.

Vergne Y, Matta J, Morales L, Vargas W, Alvarez-Garriga C, Bayona M Integr Med (Encinitas). 2014; 12(3):38-46.

PMID: 24817834 PMC: 4012419.

Vitamin supplement consumption and breast cancer risk: a review.

Misotti A, Gnagnarella P Ecancermedicalscience. 2013; 7:365.

PMID: 24171049 PMC: 3805144. DOI: 10.3332/ecancer.2013.365.

Multivitamin use and breast cancer outcomes in women with early-stage breast cancer: the Life After Cancer Epidemiology study.

Kwan M, Greenlee H, Lee V, Castillo A, Gunderson E, Habel L Breast Cancer Res Treat. 2011; 130(1):195-205.

PMID: 21559824 PMC: 3272363. DOI: 10.1007/s10549-011-1557-4.

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