Inositol 1,4,5-triphosphate Phosphatase Activity in Membranes Isolated from Amphibian Skeletal Muscle [corrected]

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 1991 Feb 11

PMID 1995344

Citations 5

Authors

X Sanchez

M A Carrasco

J Vergara

C Hidalgo

Affiliations

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Abstract

The hydrolysis of [3H]inositol 1,4,5-trisphosphate by a soluble fraction and by isolated transverse tubule and sarcoplasmic reticulum membranes from frog skeletal muscle was studied. Transverse tubule membranes displayed rates of hydrolysis several-fold higher than those of sacroplasmic reticulum and soluble fraction; Km and Vmax were 25.2 microM and 44.1 nmol/mg/min, respectively. Transverse tubule membranes sequentially hydrolyzed inositol trisphosphate to inositol bisphosphate, inositol 1-phosphate and inositol, indicating that these membranes have inositol bis- and monophosphatases in addition to inositol trisphosphatase.

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