BRD2 and TAP-1 Genes and Juvenile Myoclonic Epilepsy

Overview

Journal Neurol Sci

Specialty Neurology

Date 2009 Dec 3

PMID 19953286

Citations 7

Authors

Samia Layouni

Catherine Buresi

Pierre Thomas

Alain Malafosse

Mohamed Dogui

Affiliations

Soon will be listed here.

Abstract

Juvenile myoclonic epilepsy (JME) is a genetically determined common subtype of idiopathic generalized epilepsy. Linkage of JME to the chromosomal region 6p21.3 has been reported. An association has been previously observed between JME and the positional candidate, 6p21.3 linked, BRD2. Another candidate in this region is the TAP-1 gene encoding the Transporter Associated with Antigen Processing. The aim of the present study is to determine whether these two genes modulate the vulnerability to JME. While no difference was observed in the allele and genotype frequencies of BRD2 between JME and controls, an association was found between a TAP-1 haplotype and JME, suggesting that this gene may be another 6p21.3 linked vulnerability factor to JME.

Citing Articles

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DNA methylation of the BRD2 promoter is associated with juvenile myoclonic epilepsy in Caucasians.

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Genetic susceptibility in Juvenile Myoclonic Epilepsy: Systematic review of genetic association studies.

Dos Santos B, Marinho C, Marques T, Angelo L, Malta M, Duzzioni M PLoS One. 2017; 12(6):e0179629.

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Association of the GRM4 gene variants with juvenile myoclonic epilepsy in an Indian population.

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