Is HIV-associated Tuberculosis a Risk Factor for the Development of Cryptococcal Disease?

Overview

Journal AIDS

Specialty Infectious Diseases

Date 2009 Dec 3

PMID 19952711

Citations 16

Authors

Joseph N Jarvis

Thomas S Harrison

Elizabeth L Corbett

Robin Wood

Stephen D Lawn

Affiliations

Soon will be listed here.

Abstract

Cryptococcal meningitis and tuberculosis are leading causes of mortality in patients initiating antiretroviral therapy in Africa. We hypothesized that a history of tuberculosis may predispose to the development of cryptococcal meningitis and examined the association using multivariate logistic regression in a cohort of patients initiating antiretroviral therapy. History of pulmonary tuberculosis was independently associated with the development of cryptococcal meningitis (odds ratio = 6.6; 95% confidence interval = 1.3-32.7) after adjustment for covariates, including CD4 cell counts. A number of potential mechanisms may underlie this association.

Citing Articles

Association of Antibody Immunity With Cryptococcal Antigenemia and Mortality in a South African Cohort With Advanced Human Immunodeficiency Virus Disease.

Yoon H, Wake R, Nakouzi A, Wang T, Agalliu I, Tiemessen C Clin Infect Dis. 2022; 76(4):649-657.

PMID: 35915964 PMC: 10226730. DOI: 10.1093/cid/ciac633.

Prior Pulmonary Tuberculosis Is a Risk Factor for Asymptomatic Cryptococcal Antigenemia in a Cohort of Adults With Advanced Human Immunodeficiency Virus Disease.

Wake R, Ismail N, Omar S, Ismail F, Tiemessen C, Harrison T Open Forum Infect Dis. 2022; 9(7):ofac202.

PMID: 35794929 PMC: 9251663. DOI: 10.1093/ofid/ofac202.

CNS cryptococcosis presenting with cerebellar stroke and spinal arachnoiditis.

Priyadarshi M, Tirlangi P, Kadnur H, Jadon R BMJ Case Rep. 2022; 15(2).

PMID: 35131790 PMC: 8823087. DOI: 10.1136/bcr-2021-246824.

Pathways to care and outcomes among hospitalised HIV-seropositive persons with cryptococcal meningitis in South Africa.

Quan V, Toro-Silva S, Sriruttan C, Chetty V, Chihota V, Candfield S PLoS One. 2019; 14(12):e0225742.

PMID: 31830060 PMC: 6907845. DOI: 10.1371/journal.pone.0225742.

Tuberculosis in Hospitalized Patients With Human Immunodeficiency Virus: Clinical Characteristics, Mortality, and Implications From the Rapid Urine-based Screening for Tuberculosis to Reduce AIDS Related Mortality in Hospitalized Patients in Africa.

Gupta-Wright A, Fielding K, Wilson D, van Oosterhout J, Grint D, Mwandumba H Clin Infect Dis. 2019; 71(10):2618-2626.

PMID: 31781758 PMC: 7744971. DOI: 10.1093/cid/ciz1133.

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