Prevention of Steatosis by Hepatic JNK1

Overview

Journal Cell Metab

Publisher Cell Press

Specialties Cell Biology
Endocrinology

Date 2009 Dec 1

PMID 19945406

Citations 89

Authors

Guadalupe Sabio

Julie Cavanagh-Kyros

Hwi Jin Ko

Dae Young Jung

Susan Gray

John Y Jun

Tamera Barrett

Alfonso Mora

Jason K Kim

Roger J Davis

Affiliations

Soon will be listed here.

Abstract

Nonalcoholic steatosis (fatty liver) is a major cause of liver dysfunction that is associated with insulin resistance and metabolic syndrome. The cJun NH(2)-terminal kinase 1 (JNK1) signaling pathway is implicated in the pathogenesis of hepatic steatosis and drugs that target JNK1 may be useful for treatment of this disease. Indeed, mice with defects in JNK1 expression in adipose tissue are protected against hepatic steatosis. Here we report that mice with specific ablation of Jnk1 in hepatocytes exhibit glucose intolerance, insulin resistance, and hepatic steatosis. JNK1 therefore serves opposing actions in liver and adipose tissue to both promote and prevent hepatic steatosis. This finding has potential implications for the design of JNK1-selective drugs for the treatment of metabolic syndrome.

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