Demographic Data of Laryngeal Cancer at the Instituto Nacional De Cancerología in Mexico City

Background: We undertook this study to describe the demographic data of patients with laryngeal cancer treated at the Instituto Nacional de Cancerología in Mexico City.

Methods: We retrospectively reviewed the clinical files from 1986 to 2002, revealing 500 patients.

Results: Included were 452 men (90.4%) and 48 women (9.6%) (M:F ratio--10.6:1). Average age of patients was 62.37 years. The highest incidence of patients was among those aged 56 to 70 years. Smoking and alcoholism were present in most patients from this series. The cardinal symptom of presentation was dysphonia in 458 patients (91.6%). The mean evolution time of symptomatology was 11.6 months. The most common localization of the tumor was the glottis (61.6%). One hundred forty two patients (28.4%) presented early-stage tumors (T1-T2) and 354 patients (70.8%) presented with late-stage tumors (T3-T4). Clinically, 165 patients (33.0%) presented adenopathies and 13 patients (2.6%) had metastases at the time of diagnosis; 483 patients (96.6%) presented with invasive epidermoid cancer. Of these, 325 patients received treatment. One hundred forty six patients (44.9%) presented local recurrence, in nine patients (2.8%) there was regional recurrence, and one patient (0.3%) recurred with a distant tumor. Adequate control of the primary tumor was achieved with the established treatment in 169 patients (52%). verage survival time of the 325 treated patients was 38 months.

Conclusions: Cancer of the larynx is a potentially curable entity. In any patient with major dysphonia of >1 month evolution, a differential diagnosis of cancer must be made. The survival prognosis for patients with cancer of the larynx is determined by the initial clinical stage.