25-Hydroxyvitamin D Levels and Cognitive Performance and Decline in Elderly Men

Overview

Journal Neurology

Specialty Neurology

Date 2009 Nov 27

PMID 19940271

Citations 70

Authors

Y Slinin

M L Paudel

B C Taylor

H A Fink

A Ishani

M T Canales

K Yaffe

E Barrett-Connor

E S Orwoll

J M Shikany

E S LeBlanc

J A Cauley

K E Ensrud

Affiliations

Soon will be listed here.

Abstract

Objective: To test the hypothesis that lower 25-hydroxyvitamin D [25(OH)D] levels are associated with a greater likelihood of cognitive impairment and risk of cognitive decline.

Methods: We measured 25(OH)D and assessed cognitive function using the Modified Mini-Mental State Examination (3MS) and Trail Making Test Part B (Trails B) in a cohort of 1,604 men enrolled in the Osteoporotic Fractures in Men Study and followed them for an average of 4.6 years for changes in cognitive function.

Results: In a model adjusted for age, season, and site, men with lower 25(OH)D levels seemed to have a higher odds of cognitive impairment, but the test for trend did not reach significance (impairment by 3MS: odds ratio [OR] 1.84, 95% confidence interval [CI] 0.81-4.19 for quartile [Q] 1; 1.41, 0.61-3.28 for Q2; and 1.18, 0.50-2.81 for Q3, compared with Q4 [referent group; p trend = 0.12]; and impairment by Trails B: OR 1.66, 95% CI 0.98-2.82 for Q1; 0.96, 0.54-1.69 for Q2; and 1.30, 0.76-2.22 for Q3, compared with Q4 [p trend = 0.12]). Adjustment for age and education further attenuated the relationships. There was a trend for an independent association between lower 25(OH)D levels and odds of cognitive decline by 3MS performance (multivariable OR 1.41, 95% CI 0.89-2.23 for Q1; 1.28, 0.84-1.95 for Q2; and 1.06, 0.70-1.62 for Q3, compared with Q4 [p = 0.10]), but no association with cognitive decline by Trails B.

Conclusion: We found little evidence of independent associations between lower 25-hydroxyvitamin D level and baseline global and executive cognitive function or incident cognitive decline.

Citing Articles

Follow-Up Period Affects the Association between Serum 25-Hydroxyvitamin D Concentration and Incidence of Dementia, Alzheimer's Disease, and Cognitive Impairment.

Grant W Nutrients. 2024; 16(18).

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Associations of empirically derived dietary patterns and cognitive performance in older men: Results of the Osteoporotic Fractures in Men (MrOS) study.

Rogers-Soeder T, Patel S, Shikany J, Langsetmo L, Judd S, Ensrud K Maturitas. 2024; 186:108030.

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Jain S, Stevens C, Margret J, Levine S Antioxid Redox Signal. 2023; 40(10-12):663-678.

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Is There a Role of Vitamin D in Alzheimer's Disease?.

Plantone D, Pardini M, Caneva S, De Stefano N CNS Neurol Disord Drug Targets. 2023; 23(5):545-553.

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Association between vitamin D concentration and delirium in hospitalized patients: A meta-analysis.

Fu N, Miao M, Li N, Zeng S, Zhu R, Zhang J PLoS One. 2023; 18(2):e0281313.

PMID: 36753475 PMC: 9907811. DOI: 10.1371/journal.pone.0281313.

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