Fluorescence Tomographic Imaging Using a Handheld-probe-based Optical Imager: Extensive Phantom Studies

Overview

Journal Appl Opt

Date 2009 Nov 26

PMID 19935959

Citations 7

Authors

Jiajia Ge

Sarah J Erickson

Anuradha Godavarty

Affiliations

Soon will be listed here.

Abstract

Handheld-probe-based optical imagers are a popular approach toward breast imaging because of their potential portability and maximum patient comfort. A novel handheld-probe-based optical imager has been developed and its feasibility for three-dimensional fluorescence tomographic imaging demonstrated. Extensive tomography studies were performed on large slab phantoms (650 ml) to assess the performance limits of the handheld imager. Experiments were performed by using different target volumes (0.1-0.45 cm3), target depths (1-3 cm), and fluorescence (Indocyanine Green) absorption contrast ratios in a nonfluorescing (1:0) and constant fluorescing backgrounds (1000:1 to 5:1). The estimated sensitivity and specificity of the handheld imager are 43% and 95%, respectively.

Citing Articles

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